FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966129780> ?p ?o ?g. }

• W1966129780 endingPage "7" @default.
• W1966129780 startingPage "1" @default.
• W1966129780 abstract "Cyclic guanosine-3',5'-monophoshate (cGMP) is the common second messenger for the cardiovascular effects of nitric oxide (NO) and natriuretic peptides (NP; e.g. atrial NP [ANP]), which activate soluble and particulate guanylyl cyclases, respectively. The role of NO in regulating cGMP and platelet function is well documented, whereas there is little evidence supporting a role for NPs in regulating platelet reactivity. By studying platelet aggregation and secretion in response to a PAR-1 peptide, collagen and ADP, and phosphorylation of the cGMP-dependent protein kinase (PKG) substrate vasodilator-stimulated phosphoprotein (VASP) at serine 239, we evaluated the effects of NPs in the absence or presence of the non-selective cGMP and cAMP phosphodiesterase (PDE) inhibitor, 3-isobutyl-1-methylxanthine (IBMX). Our results show that NPs, possibly through the clearance receptor (natriuretic peptide receptor-C) expressed on platelet membranes, increase VASP phosphorylation but only following PDE inhibition, indicating a small, localised cGMP synthesis. As platelet aggregation and secretion measured under the same conditions were not affected, we conclude that the magnitude of PKG activation achieved by NPs in platelets per se is not sufficient to exert functional inhibition of platelet involvement in haemostasis." @default.
• W1966129780 created "2016-06-24" @default.
• W1966129780 creator A5005426443 @default.
• W1966129780 creator A5057189590 @default.
• W1966129780 creator A5057799772 @default.
• W1966129780 creator A5068995460 @default.
• W1966129780 date "2013-03-07" @default.
• W1966129780 modified "2023-10-16" @default.
• W1966129780 title "Natriuretic peptides induce weak VASP phosphorylation at Serine 239 in platelets" @default.
• W1966129780 cites W1526841021 @default.
• W1966129780 cites W1851039170 @default.
• W1966129780 cites W1975906565 @default.
• W1966129780 cites W1986444795 @default.
• W1966129780 cites W1989992071 @default.
• W1966129780 cites W1995278218 @default.
• W1966129780 cites W2003456413 @default.
• W1966129780 cites W2014731651 @default.
• W1966129780 cites W2017434935 @default.
• W1966129780 cites W2019861198 @default.
• W1966129780 cites W2024862370 @default.
• W1966129780 cites W2034172202 @default.
• W1966129780 cites W2042639821 @default.
• W1966129780 cites W2049484081 @default.
• W1966129780 cites W2053232655 @default.
• W1966129780 cites W2070531791 @default.
• W1966129780 cites W2081065182 @default.
• W1966129780 cites W2084077120 @default.
• W1966129780 cites W2086948789 @default.
• W1966129780 cites W2097688301 @default.
• W1966129780 cites W2111541126 @default.
• W1966129780 cites W2115993532 @default.
• W1966129780 cites W2122414904 @default.
• W1966129780 cites W2320615300 @default.
• W1966129780 cites W2410733370 @default.
• W1966129780 cites W4229755335 @default.
• W1966129780 doi "https://doi.org/10.3109/09537104.2013.773969" @default.
• W1966129780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3886897" @default.
• W1966129780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23469931" @default.
• W1966129780 hasPublicationYear "2013" @default.
• W1966129780 type Work @default.
• W1966129780 sameAs 1966129780 @default.
• W1966129780 citedByCount "7" @default.
• W1966129780 countsByYear W19661297802014 @default.
• W1966129780 countsByYear W19661297802017 @default.
• W1966129780 countsByYear W19661297802018 @default.
• W1966129780 countsByYear W19661297802021 @default.
• W1966129780 countsByYear W19661297802022 @default.
• W1966129780 crossrefType "journal-article" @default.
• W1966129780 hasAuthorship W1966129780A5005426443 @default.
• W1966129780 hasAuthorship W1966129780A5057189590 @default.
• W1966129780 hasAuthorship W1966129780A5057799772 @default.
• W1966129780 hasAuthorship W1966129780A5068995460 @default.
• W1966129780 hasBestOaLocation W19661297802 @default.
• W1966129780 hasConcept C11960822 @default.
• W1966129780 hasConcept C126322002 @default.
• W1966129780 hasConcept C134018914 @default.
• W1966129780 hasConcept C163235415 @default.
• W1966129780 hasConcept C170493617 @default.
• W1966129780 hasConcept C178790620 @default.
• W1966129780 hasConcept C181199279 @default.
• W1966129780 hasConcept C184235292 @default.
• W1966129780 hasConcept C185592680 @default.
• W1966129780 hasConcept C199217515 @default.
• W1966129780 hasConcept C2775915353 @default.
• W1966129780 hasConcept C2776846068 @default.
• W1966129780 hasConcept C2778069365 @default.
• W1966129780 hasConcept C2778198053 @default.
• W1966129780 hasConcept C2779276759 @default.
• W1966129780 hasConcept C2781298581 @default.
• W1966129780 hasConcept C3018697912 @default.
• W1966129780 hasConcept C3156946 @default.
• W1966129780 hasConcept C519581460 @default.
• W1966129780 hasConcept C55493867 @default.
• W1966129780 hasConcept C62826618 @default.
• W1966129780 hasConcept C71924100 @default.
• W1966129780 hasConcept C86803240 @default.
• W1966129780 hasConcept C8741621 @default.
• W1966129780 hasConcept C89560881 @default.
• W1966129780 hasConcept C90934575 @default.
• W1966129780 hasConcept C97029542 @default.
• W1966129780 hasConceptScore W1966129780C11960822 @default.
• W1966129780 hasConceptScore W1966129780C126322002 @default.
• W1966129780 hasConceptScore W1966129780C134018914 @default.
• W1966129780 hasConceptScore W1966129780C163235415 @default.
• W1966129780 hasConceptScore W1966129780C170493617 @default.
• W1966129780 hasConceptScore W1966129780C178790620 @default.
• W1966129780 hasConceptScore W1966129780C181199279 @default.
• W1966129780 hasConceptScore W1966129780C184235292 @default.
• W1966129780 hasConceptScore W1966129780C185592680 @default.
• W1966129780 hasConceptScore W1966129780C199217515 @default.
• W1966129780 hasConceptScore W1966129780C2775915353 @default.
• W1966129780 hasConceptScore W1966129780C2776846068 @default.
• W1966129780 hasConceptScore W1966129780C2778069365 @default.
• W1966129780 hasConceptScore W1966129780C2778198053 @default.
• W1966129780 hasConceptScore W1966129780C2779276759 @default.
• W1966129780 hasConceptScore W1966129780C2781298581 @default.
• W1966129780 hasConceptScore W1966129780C3018697912 @default.
• W1966129780 hasConceptScore W1966129780C3156946 @default.

• next