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- W1966133777 abstract "A 20-year-old female presented with thyrotoxicosis associated with amenorrhoea and galactorrhoea after oral contraceptive withdrawal. Serum TSH was persistently elevated (mean: 28 +/- 3.1 microU/ml during 24-h sampling and did not vary significantly after TRH, bromocriptine or somatostatin. Prolactin levels remained constantly at the upper limit of normal (mean: 20.6 +/- 2.1 ng/ml, with a minimal increase after TRH, a slight decrease after somatostatin (54%) and a marked decrease after bromocriptine (88.5%). Surgical exploration revealed an unusually firm tumour adherant to the wall of the sella turcia; electron microscopic study showed that it was composed almost exclusively of thyrotrophs. After a transient period of euthyroidism post-operatively, T3 toxicosis occurred with an increased TSH level (15.5 microU/ml) and a rise in TSH and alpha subunit in response to TRH. An increase in T4 followed while prolactin remained low." @default.
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- W1966133777 date "1980-01-01" @default.
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- W1966133777 title "HYPERTHYROIDISM DUE TO A PITUITARY TSH SECRETING TUMOUR WITH AMENORRHOEA-GALACTORRHOEA" @default.
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- W1966133777 doi "https://doi.org/10.1111/j.1365-2265.1980.tb03127.x" @default.
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