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- W1966142757 abstract "The LexA repressor from Escherichla coll Induces DNA bending upon Interaction with the two overlapping operators which regulate the transcription of the colldn A encoding gene caa. Both caa operators harbor T-tracts adjacent to their recognition motifs. These tracts have been suggested to be especially favorable for the promotion of LexA-induced DNA bending. Here we show that this Is Indeed the case, since disruption of the TTTT-tract adjacent to operator 01 by the replacement of the two central thymlne bases by AA, GA or CG markedly reduces LexA-induced DNA bending. Simple A-T-rlchness In this position Is thus not sufficient to promote full LexA-induced bending, albeit a TAAT sequence Is always more efficient to promote bending than those sequences containing one or two C/G base pairs." @default.
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- W1966142757 date "1993-01-01" @default.
- W1966142757 modified "2023-10-18" @default.
- W1966142757 title "DNA sequence determinants of LexA-induced DNA bending" @default.
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- W1966142757 doi "https://doi.org/10.1093/nar/21.10.2363" @default.
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