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- W1966152054 abstract "Metabolism of pyridalyl [2,6-dichloro-4-(3,3-dichloroallyloxy)phenyl 3-[5-(trifluoromethyl)-2-pyridyloxy]propyl ether] labeled at position 2 of the dichloropropenyl group with 14C was investigated after single oral administration to male and female rats at 5 and 500 mg/kg. Absorbed 14C was excreted into feces (68−79%), urine (8−14%), and expired air (6−10%) in all of the groups. Regarding 14C-tissue residues on the seventh day after administration, fat showed the highest levels at 0.98−2.34 ppm and 219−221 ppm with the low and high doses, respectively. 14C-Residues in other tissues accounted for 0.03−0.32 ppm at the low dose and 3−70 ppm at the high dose. The percentages of the 14C-residue in fat were 1.50−3.16% of the dose, and those of muscle and hair and skin were also relatively high, accounting for 0.49−1.20%. Total 14C-residues in the whole body were 2.95−6.80% of the dose. Fecal metabolites in male rats treated with 500 mg/kg pyridalyl were purified by a combination of chromatographic techniques, and chemical structures of 8 metabolites were identified by NMR and MS spectrometry. The biotransformation reactions in rats were proposed to be as follows: (1) epoxidation of the double bond in the dichloropropenyl group followed by hydration, dehydrochlorination, decarboxylation, and/or mercapturic acid conjugation; (2) CO2 formation after O-dealkylation of pyridalyl and its metabolites; (3) hydroxylation of C3 in the pyridyl ring; (4) O-dealkylation of the pyridyloxy and the trimethylene groups; (5) dehydrochlorination and hydration in the dichloropropenyl group." @default.
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- W1966152054 date "2009-10-27" @default.
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- W1966152054 title "Metabolism of Pyridalyl in Rats: Excretion, Distribution, and Biotransformation of Dichloropropenyl-Labeled Pyridalyl" @default.
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- W1966152054 doi "https://doi.org/10.1021/jf9026469" @default.
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