FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966154123> ?p ?o ?g. }

• W1966154123 endingPage "e9814" @default.
• W1966154123 startingPage "e9814" @default.
• W1966154123 abstract "In a previous study, progesterone treatment of female monkeys immunized with live, attenuated SHIV89.6 abrogated the generally consistent protection from vaginal simian immunodeficiency virus (SIV) challenge. The mechanisms responsible for the loss of protection remain to be defined. The objective of the present study was to determine whether Depo-Provera administration alters protection from intravenous SIV challenge in SHIV-immunized female macaques.Two groups of female macaques were immunized with attenuated SHIV89.6 and then challenged intravenously with SIVmac239. Four weeks before challenge, one animal group was treated with Depo-Provera, a commonly used injectable contraceptive progestin. As expected, SHIV-immunized monkeys had significantly lower peak and set-point plasma viral RNA levels compared to naïve controls, but in contrast to previously published findings with vaginal SIV challenge, the Depo-Provera SHIV-immunized animals controlled SIV replication to a similar, or even slightly greater, degree than did the untreated SHIV-immunized animals. Control of viral replication from week 4 to week 20 after challenge was more consistent in the progesterone-treated, SHIV-immunized animals than in untreated, SHIV-immunized animals. Although levels of interferon-gamma production were similar, the SIV-specific CD8(+) T cells of progesterone-treated animals expressed more functions than the anti-viral CD8(+) T cells from untreated animals.Depo-Provera did not diminish the control of viral replication after intravenous SIV challenge in female macaques immunized with a live-attenuated lentivirus. This result contrasts with the previously reported effect of Depo-Provera(R) on protection from vaginal SIV challenge and strongly implies that the decreased protection from vaginal challenge is due to effects of progesterone on the genital tract rather than to systemic effects. Further, these results demonstrate that the effects of hormonal contraceptives on vaccine efficacy need to be considered in the context of testing and use of an AIDS vaccine." @default.
• W1966154123 created "2016-06-24" @default.
• W1966154123 creator A5033595975 @default.
• W1966154123 creator A5089037138 @default.
• W1966154123 creator A5089085793 @default.
• W1966154123 date "2010-03-23" @default.
• W1966154123 modified "2023-10-17" @default.
• W1966154123 title "Depo-Provera® Treatment Does Not Abrogate Protection from Intravenous SIV Challenge in Female Macaques Immunized with an Attenuated AIDS Virus" @default.
• W1966154123 cites W1552674833 @default.
• W1966154123 cites W1654759719 @default.
• W1966154123 cites W1779647240 @default.
• W1966154123 cites W1921538198 @default.
• W1966154123 cites W1967020365 @default.
• W1966154123 cites W1979822374 @default.
• W1966154123 cites W1984519433 @default.
• W1966154123 cites W1999786336 @default.
• W1966154123 cites W2002213384 @default.
• W1966154123 cites W2005121414 @default.
• W1966154123 cites W2013695708 @default.
• W1966154123 cites W2015176800 @default.
• W1966154123 cites W2037995039 @default.
• W1966154123 cites W2038018492 @default.
• W1966154123 cites W2057023184 @default.
• W1966154123 cites W2065518048 @default.
• W1966154123 cites W2076776977 @default.
• W1966154123 cites W2089912966 @default.
• W1966154123 cites W2107737102 @default.
• W1966154123 cites W2115002228 @default.
• W1966154123 cites W2129894412 @default.
• W1966154123 cites W2131743669 @default.
• W1966154123 cites W2136654644 @default.
• W1966154123 cites W2145087629 @default.
• W1966154123 cites W2145470673 @default.
• W1966154123 cites W2163369593 @default.
• W1966154123 cites W2165635529 @default.
• W1966154123 doi "https://doi.org/10.1371/journal.pone.0009814" @default.
• W1966154123 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2843738" @default.
• W1966154123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20352116" @default.
• W1966154123 hasPublicationYear "2010" @default.
• W1966154123 type Work @default.
• W1966154123 sameAs 1966154123 @default.
• W1966154123 citedByCount "9" @default.
• W1966154123 countsByYear W19661541232012 @default.
• W1966154123 countsByYear W19661541232013 @default.
• W1966154123 countsByYear W19661541232014 @default.
• W1966154123 countsByYear W19661541232015 @default.
• W1966154123 countsByYear W19661541232016 @default.
• W1966154123 countsByYear W19661541232021 @default.
• W1966154123 crossrefType "journal-article" @default.
• W1966154123 hasAuthorship W1966154123A5033595975 @default.
• W1966154123 hasAuthorship W1966154123A5089037138 @default.
• W1966154123 hasAuthorship W1966154123A5089085793 @default.
• W1966154123 hasBestOaLocation W19661541231 @default.
• W1966154123 hasConcept C140704245 @default.
• W1966154123 hasConcept C142462285 @default.
• W1966154123 hasConcept C151730666 @default.
• W1966154123 hasConcept C159047783 @default.
• W1966154123 hasConcept C167672396 @default.
• W1966154123 hasConcept C203014093 @default.
• W1966154123 hasConcept C2522874641 @default.
• W1966154123 hasConcept C2777995582 @default.
• W1966154123 hasConcept C2778950215 @default.
• W1966154123 hasConcept C2779690655 @default.
• W1966154123 hasConcept C2780727368 @default.
• W1966154123 hasConcept C71924100 @default.
• W1966154123 hasConcept C86803240 @default.
• W1966154123 hasConcept C8891405 @default.
• W1966154123 hasConceptScore W1966154123C140704245 @default.
• W1966154123 hasConceptScore W1966154123C142462285 @default.
• W1966154123 hasConceptScore W1966154123C151730666 @default.
• W1966154123 hasConceptScore W1966154123C159047783 @default.
• W1966154123 hasConceptScore W1966154123C167672396 @default.
• W1966154123 hasConceptScore W1966154123C203014093 @default.
• W1966154123 hasConceptScore W1966154123C2522874641 @default.
• W1966154123 hasConceptScore W1966154123C2777995582 @default.
• W1966154123 hasConceptScore W1966154123C2778950215 @default.
• W1966154123 hasConceptScore W1966154123C2779690655 @default.
• W1966154123 hasConceptScore W1966154123C2780727368 @default.
• W1966154123 hasConceptScore W1966154123C71924100 @default.
• W1966154123 hasConceptScore W1966154123C86803240 @default.
• W1966154123 hasConceptScore W1966154123C8891405 @default.
• W1966154123 hasIssue "3" @default.
• W1966154123 hasLocation W19661541231 @default.
• W1966154123 hasLocation W19661541232 @default.
• W1966154123 hasLocation W19661541233 @default.
• W1966154123 hasLocation W19661541234 @default.
• W1966154123 hasOpenAccess W1966154123 @default.
• W1966154123 hasPrimaryLocation W19661541231 @default.
• W1966154123 hasRelatedWork W1531068485 @default.
• W1966154123 hasRelatedWork W2006042633 @default.
• W1966154123 hasRelatedWork W2061109312 @default.
• W1966154123 hasRelatedWork W2072794122 @default.
• W1966154123 hasRelatedWork W2082347526 @default.
• W1966154123 hasRelatedWork W2090251528 @default.
• W1966154123 hasRelatedWork W2105028368 @default.
• W1966154123 hasRelatedWork W2119739349 @default.
• W1966154123 hasRelatedWork W2127289222 @default.
• W1966154123 hasRelatedWork W2155048514 @default.

• next