FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W196615512> ?p ?o ?g. }

• W196615512 endingPage "635" @default.
• W196615512 startingPage "630" @default.
• W196615512 abstract "This study sought to examine the possible drug–drug interactions between clopidogrel and morphine. Because morphine—the recommended treatment for pain of myocardial infarction—is associated with poor clinical outcome, we hypothesized that morphine lowers the plasma levels of clopidogrel active metabolite as well as its effects on platelets. Twenty-four healthy subjects received a loading dose of 600 mg clopidogrel together with placebo or 5 mg morphine intravenously in a randomized, double-blind, placebo-controlled, cross-over trial. Pharmacokinetics was determined by liquid chromatography tandem mass spectrometry, and clopidogrel effects were measured by platelet function tests. Morphine injection delayed clopidogrel absorption (p = 0.025) and reduced the area under the curve levels of its active metabolite by 34% (p = 0.001). Morphine delayed the maximal inhibition of platelet aggregation on average by 2 h (n = 24; p < 0.001). Residual platelet aggregation was higher 1 to 4 h after morphine injection (n = 24; p < 0.005). Furthermore, morphine delayed the inhibition of platelet plug formation under high shear rates (P2Y-Innovance; n = 21; p < 0.004) and abolished the 3-fold prolongation in collagen adenosine diphosphate-induced closure times seen in extensive and rapid metabolizers (n = 16; p = 0.001). Morphine delays clopidogrel absorption, decreases plasma levels of clopidogrel active metabolite, and retards and diminishes its effects, which can lead to treatment failure in susceptible individuals. (Drug Drug Interactions of Aspirin and P2Y12-inhibitors; NCT01369186)" @default.
• W196615512 created "2016-06-24" @default.
• W196615512 creator A5005313310 @default.
• W196615512 creator A5011290739 @default.
• W196615512 creator A5041741017 @default.
• W196615512 creator A5046162707 @default.
• W196615512 creator A5055977594 @default.
• W196615512 creator A5059547821 @default.
• W196615512 creator A5074136047 @default.
• W196615512 creator A5078333581 @default.
• W196615512 creator A5079576359 @default.
• W196615512 creator A5080941679 @default.
• W196615512 date "2014-02-01" @default.
• W196615512 modified "2023-10-18" @default.
• W196615512 title "Morphine Decreases Clopidogrel Concentrations and Effects" @default.
• W196615512 cites W1972219082 @default.
• W196615512 cites W2008938165 @default.
• W196615512 cites W2015884906 @default.
• W196615512 cites W2018234502 @default.
• W196615512 cites W2018476171 @default.
• W196615512 cites W2018865074 @default.
• W196615512 cites W2022259640 @default.
• W196615512 cites W2026270873 @default.
• W196615512 cites W2048387792 @default.
• W196615512 cites W2048615527 @default.
• W196615512 cites W2110615148 @default.
• W196615512 cites W2118534378 @default.
• W196615512 cites W2140220482 @default.
• W196615512 cites W2161055506 @default.
• W196615512 cites W2169387542 @default.
• W196615512 cites W2170029016 @default.
• W196615512 cites W4293372203 @default.
• W196615512 cites W4296300792 @default.
• W196615512 doi "https://doi.org/10.1016/j.jacc.2013.10.068" @default.
• W196615512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24315907" @default.
• W196615512 hasPublicationYear "2014" @default.
• W196615512 type Work @default.
• W196615512 sameAs 196615512 @default.
• W196615512 citedByCount "177" @default.
• W196615512 countsByYear W1966155122014 @default.
• W196615512 countsByYear W1966155122015 @default.
• W196615512 countsByYear W1966155122016 @default.
• W196615512 countsByYear W1966155122017 @default.
• W196615512 countsByYear W1966155122018 @default.
• W196615512 countsByYear W1966155122019 @default.
• W196615512 countsByYear W1966155122020 @default.
• W196615512 countsByYear W1966155122021 @default.
• W196615512 countsByYear W1966155122022 @default.
• W196615512 countsByYear W1966155122023 @default.
• W196615512 crossrefType "journal-article" @default.
• W196615512 hasAuthorship W196615512A5005313310 @default.
• W196615512 hasAuthorship W196615512A5011290739 @default.
• W196615512 hasAuthorship W196615512A5041741017 @default.
• W196615512 hasAuthorship W196615512A5046162707 @default.
• W196615512 hasAuthorship W196615512A5055977594 @default.
• W196615512 hasAuthorship W196615512A5059547821 @default.
• W196615512 hasAuthorship W196615512A5074136047 @default.
• W196615512 hasAuthorship W196615512A5078333581 @default.
• W196615512 hasAuthorship W196615512A5079576359 @default.
• W196615512 hasAuthorship W196615512A5080941679 @default.
• W196615512 hasBestOaLocation W1966155121 @default.
• W196615512 hasConcept C112705442 @default.
• W196615512 hasConcept C126322002 @default.
• W196615512 hasConcept C142724271 @default.
• W196615512 hasConcept C149151106 @default.
• W196615512 hasConcept C204787440 @default.
• W196615512 hasConcept C27081682 @default.
• W196615512 hasConcept C2777265216 @default.
• W196615512 hasConcept C2777389121 @default.
• W196615512 hasConcept C2777399203 @default.
• W196615512 hasConcept C2777477808 @default.
• W196615512 hasConcept C2777628954 @default.
• W196615512 hasConcept C2777849778 @default.
• W196615512 hasConcept C2909112448 @default.
• W196615512 hasConcept C2993802102 @default.
• W196615512 hasConcept C42219234 @default.
• W196615512 hasConcept C49059817 @default.
• W196615512 hasConcept C71924100 @default.
• W196615512 hasConcept C76318530 @default.
• W196615512 hasConcept C89560881 @default.
• W196615512 hasConcept C98274493 @default.
• W196615512 hasConceptScore W196615512C112705442 @default.
• W196615512 hasConceptScore W196615512C126322002 @default.
• W196615512 hasConceptScore W196615512C142724271 @default.
• W196615512 hasConceptScore W196615512C149151106 @default.
• W196615512 hasConceptScore W196615512C204787440 @default.
• W196615512 hasConceptScore W196615512C27081682 @default.
• W196615512 hasConceptScore W196615512C2777265216 @default.
• W196615512 hasConceptScore W196615512C2777389121 @default.
• W196615512 hasConceptScore W196615512C2777399203 @default.
• W196615512 hasConceptScore W196615512C2777477808 @default.
• W196615512 hasConceptScore W196615512C2777628954 @default.
• W196615512 hasConceptScore W196615512C2777849778 @default.
• W196615512 hasConceptScore W196615512C2909112448 @default.
• W196615512 hasConceptScore W196615512C2993802102 @default.
• W196615512 hasConceptScore W196615512C42219234 @default.
• W196615512 hasConceptScore W196615512C49059817 @default.
• W196615512 hasConceptScore W196615512C71924100 @default.

• next