FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966155655> ?p ?o ?g. }

• W1966155655 endingPage "919" @default.
• W1966155655 startingPage "915" @default.
• W1966155655 abstract "Novel motor skills are learned through repetitive practice and, once acquired, persist long after training stops. Earlier studies have shown that such learning induces an increase in the efficacy of synapses in the primary motor cortex, the persistence of which is associated with retention of the task. However, how motor learning affects neuronal circuitry at the level of individual synapses and how long-lasting memory is structurally encoded in the intact brain remain unknown. Here we show that synaptic connections in the living mouse brain rapidly respond to motor-skill learning and permanently rewire. Training in a forelimb reaching task leads to rapid (within an hour) formation of postsynaptic dendritic spines on the output pyramidal neurons in the contralateral motor cortex. Although selective elimination of spines that existed before training gradually returns the overall spine density back to the original level, the new spines induced during learning are preferentially stabilized during subsequent training and endure long after training stops. Furthermore, we show that different motor skills are encoded by different sets of synapses. Practice of novel, but not previously learned, tasks further promotes dendritic spine formation in adulthood. Our findings reveal that rapid, but long-lasting, synaptic reorganization is closely associated with motor learning. The data also suggest that stabilized neuronal connections are the foundation of durable motor memory." @default.
• W1966155655 created "2016-06-24" @default.
• W1966155655 creator A5009925244 @default.
• W1966155655 creator A5021667771 @default.
• W1966155655 creator A5043330161 @default.
• W1966155655 creator A5055617122 @default.
• W1966155655 creator A5059478182 @default.
• W1966155655 creator A5072909325 @default.
• W1966155655 creator A5075481727 @default.
• W1966155655 creator A5077440082 @default.
• W1966155655 date "2009-11-29" @default.
• W1966155655 modified "2023-10-16" @default.
• W1966155655 title "Rapid formation and selective stabilization of synapses for enduring motor memories" @default.
• W1966155655 cites W1572640432 @default.
• W1966155655 cites W1642243794 @default.
• W1966155655 cites W1974236821 @default.
• W1966155655 cites W1980933730 @default.
• W1966155655 cites W1982482415 @default.
• W1966155655 cites W1984937521 @default.
• W1966155655 cites W2017613746 @default.
• W1966155655 cites W2054098425 @default.
• W1966155655 cites W2067071866 @default.
• W1966155655 cites W2067608252 @default.
• W1966155655 cites W2069951277 @default.
• W1966155655 cites W2074623278 @default.
• W1966155655 cites W2075358425 @default.
• W1966155655 cites W2080351494 @default.
• W1966155655 cites W2088446997 @default.
• W1966155655 cites W2090075030 @default.
• W1966155655 cites W2090319528 @default.
• W1966155655 cites W2094455233 @default.
• W1966155655 cites W2096610613 @default.
• W1966155655 cites W2098917165 @default.
• W1966155655 cites W2106267269 @default.
• W1966155655 cites W2106319887 @default.
• W1966155655 cites W2112080120 @default.
• W1966155655 cites W2127810309 @default.
• W1966155655 cites W2130183688 @default.
• W1966155655 cites W2133532809 @default.
• W1966155655 cites W2142467832 @default.
• W1966155655 cites W2142721059 @default.
• W1966155655 cites W2162407586 @default.
• W1966155655 cites W2164535356 @default.
• W1966155655 cites W2171612971 @default.
• W1966155655 doi "https://doi.org/10.1038/nature08389" @default.
• W1966155655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2844762" @default.
• W1966155655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19946267" @default.
• W1966155655 hasPublicationYear "2009" @default.
• W1966155655 type Work @default.
• W1966155655 sameAs 1966155655 @default.
• W1966155655 citedByCount "1008" @default.
• W1966155655 countsByYear W19661556552012 @default.
• W1966155655 countsByYear W19661556552013 @default.
• W1966155655 countsByYear W19661556552014 @default.
• W1966155655 countsByYear W19661556552015 @default.
• W1966155655 countsByYear W19661556552016 @default.
• W1966155655 countsByYear W19661556552017 @default.
• W1966155655 countsByYear W19661556552018 @default.
• W1966155655 countsByYear W19661556552019 @default.
• W1966155655 countsByYear W19661556552020 @default.
• W1966155655 countsByYear W19661556552021 @default.
• W1966155655 countsByYear W19661556552022 @default.
• W1966155655 countsByYear W19661556552023 @default.
• W1966155655 crossrefType "journal-article" @default.
• W1966155655 hasAuthorship W1966155655A5009925244 @default.
• W1966155655 hasAuthorship W1966155655A5021667771 @default.
• W1966155655 hasAuthorship W1966155655A5043330161 @default.
• W1966155655 hasAuthorship W1966155655A5055617122 @default.
• W1966155655 hasAuthorship W1966155655A5059478182 @default.
• W1966155655 hasAuthorship W1966155655A5072909325 @default.
• W1966155655 hasAuthorship W1966155655A5075481727 @default.
• W1966155655 hasAuthorship W1966155655A5077440082 @default.
• W1966155655 hasBestOaLocation W19661556552 @default.
• W1966155655 hasConcept C107690735 @default.
• W1966155655 hasConcept C127445978 @default.
• W1966155655 hasConcept C148762608 @default.
• W1966155655 hasConcept C15744967 @default.
• W1966155655 hasConcept C162324750 @default.
• W1966155655 hasConcept C169760540 @default.
• W1966155655 hasConcept C169976356 @default.
• W1966155655 hasConcept C170493617 @default.
• W1966155655 hasConcept C174884520 @default.
• W1966155655 hasConcept C187736073 @default.
• W1966155655 hasConcept C197341189 @default.
• W1966155655 hasConcept C24998067 @default.
• W1966155655 hasConcept C2778373776 @default.
• W1966155655 hasConcept C2778646069 @default.
• W1966155655 hasConcept C2780307956 @default.
• W1966155655 hasConcept C2780451532 @default.
• W1966155655 hasConcept C55493867 @default.
• W1966155655 hasConcept C86803240 @default.
• W1966155655 hasConceptScore W1966155655C107690735 @default.
• W1966155655 hasConceptScore W1966155655C127445978 @default.
• W1966155655 hasConceptScore W1966155655C148762608 @default.
• W1966155655 hasConceptScore W1966155655C15744967 @default.
• W1966155655 hasConceptScore W1966155655C162324750 @default.
• W1966155655 hasConceptScore W1966155655C169760540 @default.
• W1966155655 hasConceptScore W1966155655C169976356 @default.

• next