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• W1966157002 abstract "Structure−activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogues. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthesis that produced more than 30 mg of 6-epi-dictyostatin. The compound was found to have potent antitumor activity in SCID mice bearing MDA-MB231 human breast cancer xenografts." @default.
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• W1966157002 date "2008-10-08" @default.
• W1966157002 modified "2023-10-07" @default.
• W1966157002 title "Improved Synthesis of 6-<i>epi</i>-Dictyostatin and Antitumor Efficacy in Mice Bearing MDA-MB231 Human Breast Cancer Xenografts" @default.
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• W1966157002 doi "https://doi.org/10.1021/jm800979v" @default.
• W1966157002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2627582" @default.
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