FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966157223> ?p ?o ?g. }

• W1966157223 endingPage "461" @default.
• W1966157223 startingPage "443" @default.
• W1966157223 abstract "Abstract Structural understanding of DNA triplexes is grossly inadequate despite their efficacy as therapeutic agents. Lack of structural similarity (isomorphism) of base triplets that figure in different DNA triplexes brings in an added complexity. Recently, we have shown that the residual twist (Δ t °) and the radial difference (Δ r Å) adequately define base triplet nonisomorphism in structural terms and allow assessment of their role in conferring stability as well as sequence‐dependent structural variations in DNA triplexes. To further corroborate these, molecular dynamics (MD) simulations are carried out on DNA triplexes comprising nonisomorphic G∗︁ GC and A∗︁ AT base triplets under different sequential contexts. Base triplet nonisomorphism between G∗︁ GC and A∗︁ AT triplets is dominated by Δ t ° (9.8°), in view of small Δ r (0.2 Å), and is in contrast to G∗︁ GC and T∗︁ AT triplets where both Δ t ° (10.6°) and Δ r (1.1Å) are prominent. Results show that Δ t ° alone enforces mechanistic influence on the triplex‐forming purine strand so as to favor a zigzag conformation with alternating conformational features that include high (40°) and low (20°) helical twists, and high anti (G) and anti (A) glycosyl conformation. Higher thermal stability of this triplex compared to that formed with G∗︁ GC and T∗︁ AT triplets can be traced to enhanced base‐stacking and counterion interactions. Surprisingly, it is found for the first time that the presence of a nonisomorphic G∗︁ GC or A∗︁ AT base triplet interrupting an otherwise mini A∗︁ AT or G∗︁ GC isomorphic triplex can induce a bend/curvature in a DNA triplex. These observations should prove useful in the design of triplex‐forming oligonucleotides and in the understanding the binding affinities of this triplex with proteins. © 2006 Wiley Periodicals, Inc. Biopolymers 82: 443–461, 2006 This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com" @default.
• W1966157223 created "2016-06-24" @default.
• W1966157223 creator A5000179508 @default.
• W1966157223 creator A5001368964 @default.
• W1966157223 date "2006-02-21" @default.
• W1966157223 modified "2023-10-15" @default.
• W1966157223 title "Base triplet nonisomorphism strongly influences DNA triplex conformation: Effect of nonisomorphic G∗︁ GC and A∗︁ AT triplets and bending of DNA triplexes" @default.
• W1966157223 cites W146312310 @default.
• W1966157223 cites W1483752865 @default.
• W1966157223 cites W1491179232 @default.
• W1966157223 cites W1517794590 @default.
• W1966157223 cites W1608271215 @default.
• W1966157223 cites W1968199263 @default.
• W1966157223 cites W1970033940 @default.
• W1966157223 cites W1971722676 @default.
• W1966157223 cites W1980722147 @default.
• W1966157223 cites W1982096794 @default.
• W1966157223 cites W1982437502 @default.
• W1966157223 cites W1994064477 @default.
• W1966157223 cites W1998650223 @default.
• W1966157223 cites W2004059420 @default.
• W1966157223 cites W2005500991 @default.
• W1966157223 cites W2014264543 @default.
• W1966157223 cites W2014849186 @default.
• W1966157223 cites W2024125884 @default.
• W1966157223 cites W2030001987 @default.
• W1966157223 cites W2030036223 @default.
• W1966157223 cites W2032463558 @default.
• W1966157223 cites W2035687084 @default.
• W1966157223 cites W2038985545 @default.
• W1966157223 cites W2039111227 @default.
• W1966157223 cites W2042848995 @default.
• W1966157223 cites W2045366550 @default.
• W1966157223 cites W2049777031 @default.
• W1966157223 cites W2052329232 @default.
• W1966157223 cites W2054436897 @default.
• W1966157223 cites W2055069311 @default.
• W1966157223 cites W2058867131 @default.
• W1966157223 cites W2066818463 @default.
• W1966157223 cites W2067544866 @default.
• W1966157223 cites W2070235053 @default.
• W1966157223 cites W2073698980 @default.
• W1966157223 cites W2077281274 @default.
• W1966157223 cites W2077814400 @default.
• W1966157223 cites W2082723469 @default.
• W1966157223 cites W2083345044 @default.
• W1966157223 cites W2087942844 @default.
• W1966157223 cites W2088076921 @default.
• W1966157223 cites W2090377479 @default.
• W1966157223 cites W2094588748 @default.
• W1966157223 cites W2095703410 @default.
• W1966157223 cites W2105564521 @default.
• W1966157223 cites W2106140689 @default.
• W1966157223 cites W2106313258 @default.
• W1966157223 cites W2106655713 @default.
• W1966157223 cites W2108557919 @default.
• W1966157223 cites W2116302523 @default.
• W1966157223 cites W2122042273 @default.
• W1966157223 cites W2125289455 @default.
• W1966157223 cites W2126466006 @default.
• W1966157223 cites W2133918133 @default.
• W1966157223 cites W2135400048 @default.
• W1966157223 cites W2137313590 @default.
• W1966157223 cites W2137770909 @default.
• W1966157223 cites W2139064328 @default.
• W1966157223 cites W2149114131 @default.
• W1966157223 cites W2154574968 @default.
• W1966157223 cites W2155896775 @default.
• W1966157223 cites W2313993185 @default.
• W1966157223 cites W2327812575 @default.
• W1966157223 cites W347104212 @default.
• W1966157223 cites W4210928033 @default.
• W1966157223 cites W4232909320 @default.
• W1966157223 doi "https://doi.org/10.1002/bip.20484" @default.
• W1966157223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16493655" @default.
• W1966157223 hasPublicationYear "2006" @default.
• W1966157223 type Work @default.
• W1966157223 sameAs 1966157223 @default.
• W1966157223 citedByCount "11" @default.
• W1966157223 countsByYear W19661572232013 @default.
• W1966157223 countsByYear W19661572232015 @default.
• W1966157223 countsByYear W19661572232016 @default.
• W1966157223 countsByYear W19661572232017 @default.
• W1966157223 countsByYear W19661572232020 @default.
• W1966157223 countsByYear W19661572232021 @default.
• W1966157223 countsByYear W19661572232022 @default.
• W1966157223 crossrefType "journal-article" @default.
• W1966157223 hasAuthorship W1966157223A5000179508 @default.
• W1966157223 hasAuthorship W1966157223A5001368964 @default.
• W1966157223 hasConcept C147597530 @default.
• W1966157223 hasConcept C178790620 @default.
• W1966157223 hasConcept C185581394 @default.
• W1966157223 hasConcept C185592680 @default.
• W1966157223 hasConcept C33347731 @default.
• W1966157223 hasConcept C552990157 @default.
• W1966157223 hasConcept C55493867 @default.
• W1966157223 hasConcept C59593255 @default.
• W1966157223 hasConcept C61234307 @default.

• next