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• W1966159557 abstract "Time for primary review 29 days. Despite the abundant literature dealing with the metabolism of fatty acid in the heart, there is a limited understanding (and to the best of our knowledge no comprehensive review) concerning the role that cardiac lipid and fatty acid metabolism plays in the genesis and progression of cardiac failure.What is presently known is:1. Fatty acids and associated lipids play an important role in cardiomyocytes structure and function. There is considerable evidence that in the post-natal and adult mammalian heart, fatty acid β oxidation is the preferred pathway for the energy that is required for efficient cardiac pumping.2. Specific defects (either inherited or acquired) in mitochondrial fatty acid metabolism may cause cardiomyopathy and arrhythmias that can lead to cardiac failure.In this review, we discuss the information available concerning the molecular and cellular basis of fatty acid and lipid metabolic perturbations which can lead to cardiac failure. In this context, we will focus on the molecular and biochemical players as well as the events that occur in both the genetic abnormalities in fatty acid metabolism that lead to cardiomyopathy and cardiac failure, as well as in cardiac hypertrophy and apoptosis. The term cardiac failure is broadly used as a pathophysiologic state where the heart is unable to meet the metabolic requirements of the body. Most of this review is directed to our understanding of the mechanisms, diagnosis and treatment of fatty acid defects occurring in human cardiac failure. Experimental findings of defects in fatty acid metabolism are also discussed with respect to current and future use of animal models.Since the literature is abundant (including numerous reviews) on the subject of acquired and inherited lipid disorders in the development of coronary artery disease and stroke (e.g., cholesterol, the apolipoproteins and HDL/LDL), we have omitted these … * Corresponding author. Tel.: +1-732-22017-19; fax: +1-732-220-2992" @default.
• W1966159557 created "2016-06-24" @default.
• W1966159557 creator A5022739391 @default.
• W1966159557 creator A5079465394 @default.
• W1966159557 date "2002-06-01" @default.
• W1966159557 modified "2023-10-05" @default.
• W1966159557 title "Fatty acid metabolism in cardiac failure: biochemical, genetic and cellular analysis" @default.
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• W1966159557 doi "https://doi.org/10.1016/s0008-6363(01)00552-1" @default.
• W1966159557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12031697" @default.
• W1966159557 hasPublicationYear "2002" @default.
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