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• W1966161710 startingPage "2619" @default.
• W1966161710 abstract "A design strategy to control the thermally triggered folding, self-assembly, and subsequent hydrogelation of amphiphilic β-hairpin peptides in a pH-dependent manner is presented. Point substitutions of the lysine residues of the self-assembling peptide MAX1 were made to alter the net charge of the peptide. In turn, the electrostatic nature of the peptide directly influences the solution pH at which thermally triggered hydrogelation is permitted. CD spectroscopy and oscillatory rheology show that peptides of lower net positive charge are capable of folding and assembling into hydrogel material at lower values of pH at a given temperature. The pH sensitive folding and assembling behavior is not only dependent on the net peptide charge, but also on the exact position of substitution within the peptide sequence. TEM shows that these peptides self-assemble into hydrogels that are composed of well-defined fibrils with nonlaminated morphologies. TEM also indicates that fibril morphology is not influenced by making these sequence changes on the hydrophilic face of the hairpins. Rheology shows that the ultimate mechanical rigidity of these peptide hydrogels is dependent on the rate of folding and self-assembly. Peptides that fold and assemble faster afford more rigid gels. Ultimately, this design strategy yielded a peptide MAX1(K15E) that is capable of undergoing thermally triggered hydrogelation at physiological buffer conditions (pH 7.4, 150 NaCl, 37 °C)." @default.
• W1966161710 created "2016-06-24" @default.
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• W1966161710 date "2009-08-07" @default.
• W1966161710 modified "2023-10-01" @default.
• W1966161710 title "Tuning the pH Responsiveness of β-Hairpin Peptide Folding, Self-Assembly, and Hydrogel Material Formation" @default.
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• W1966161710 doi "https://doi.org/10.1021/bm900544e" @default.
• W1966161710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19663418" @default.
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