FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966168055> ?p ?o ?g. }

• W1966168055 endingPage "10" @default.
• W1966168055 startingPage "2" @default.
• W1966168055 abstract "Exposure to non-inherited maternal antigens (NIMA) in fetal and neonatal life of an F(1) backcross (BDF(1) female × B6 male) mouse can result in lifelong tolerance to allografts expressing the NIMA (H2(d)). We have recently shown that the NIMA-specific regulatory T cells were directly correlated with level of maternal microchimerism (MMc) in adult mice, indicating a causative link between the two, and that both Tregs and multi-lineage MMc were dependent on ingestion of milk from a NIMA(+) mother during nursing. Yet how maternal cells obtained in fetal and neonatal life are maintained in adult life remains unclear. Since stem cells are deficient in MHC class I & II expression, we hypothesized that maternally derived stem cells that replenish MMc remain throughout life without eliciting immunity, but differentiated maternal cells can either be deleted by alloreactive T and B effector cells or persist, inducing NIMA-specific tolerance. Consistent with this hypothesis, we found maternally-derived lineage(neg) c-kit(+) cells in the bone marrow of most of adult offspring by quantitative PCR; however, only 50% had detectable MMc in lineage(+) bone marrow cells. Mesenchymal stem cells (lineage(neg) and plate-adherent cells) propagated from the bone marrow also contained maternally-derived cells, albeit in 10-fold lower frequency compared with MMc in myeloid lineage (CD11b(+) and CD11c(+)) cells. Maternally-derived cardiac stem cells were also detected in lineage(neg) c-kit(+) cells purified from heart tissue of NIMA-exposed mice, indicating a local pool of stem cells sustaining MMc in a non-lymphoid tissue. Cardiac stem cell MMc correlated with the presence of maternally derived cardiomyocytes. Lastly, liver MMc increased after nursing suggesting a seeding of maternal cells into the liver via breast milk. Whether orally-derived liver MMc also included maternal stem cells, was not determined. Maternal stem cells in bone marrow and tissues of NIMA-exposed mice are likely responsible for sustaining MMc in adult mice, but their presence alone does not guarantee multi-lineage MMc and tolerance." @default.
• W1966168055 created "2016-06-24" @default.
• W1966168055 creator A5008871183 @default.
• W1966168055 creator A5066332651 @default.
• W1966168055 date "2010-07-01" @default.
• W1966168055 modified "2023-10-17" @default.
• W1966168055 title "Stem cell microchimerism and tolerance to non-inherited maternal antigens" @default.
• W1966168055 cites W1504290562 @default.
• W1966168055 cites W1521169335 @default.
• W1966168055 cites W1521725625 @default.
• W1966168055 cites W1835179263 @default.
• W1966168055 cites W1964110033 @default.
• W1966168055 cites W1976289976 @default.
• W1966168055 cites W1982122305 @default.
• W1966168055 cites W1999354901 @default.
• W1966168055 cites W2021680265 @default.
• W1966168055 cites W2024234239 @default.
• W1966168055 cites W2047003816 @default.
• W1966168055 cites W2051834269 @default.
• W1966168055 cites W2054239323 @default.
• W1966168055 cites W2055171457 @default.
• W1966168055 cites W2057510387 @default.
• W1966168055 cites W2072066004 @default.
• W1966168055 cites W2073696038 @default.
• W1966168055 cites W2076979848 @default.
• W1966168055 cites W2083370649 @default.
• W1966168055 cites W2095666785 @default.
• W1966168055 cites W2099312448 @default.
• W1966168055 cites W2139133344 @default.
• W1966168055 cites W2143020479 @default.
• W1966168055 doi "https://doi.org/10.4161/chim.1.1.12667" @default.
• W1966168055 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2995256" @default.
• W1966168055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21132055" @default.
• W1966168055 hasPublicationYear "2010" @default.
• W1966168055 type Work @default.
• W1966168055 sameAs 1966168055 @default.
• W1966168055 citedByCount "37" @default.
• W1966168055 countsByYear W19661680552012 @default.
• W1966168055 countsByYear W19661680552013 @default.
• W1966168055 countsByYear W19661680552014 @default.
• W1966168055 countsByYear W19661680552015 @default.
• W1966168055 countsByYear W19661680552016 @default.
• W1966168055 countsByYear W19661680552017 @default.
• W1966168055 countsByYear W19661680552018 @default.
• W1966168055 countsByYear W19661680552019 @default.
• W1966168055 countsByYear W19661680552020 @default.
• W1966168055 countsByYear W19661680552021 @default.
• W1966168055 countsByYear W19661680552022 @default.
• W1966168055 crossrefType "journal-article" @default.
• W1966168055 hasAuthorship W1966168055A5008871183 @default.
• W1966168055 hasAuthorship W1966168055A5066332651 @default.
• W1966168055 hasBestOaLocation W19661680551 @default.
• W1966168055 hasConcept C147483822 @default.
• W1966168055 hasConcept C159047783 @default.
• W1966168055 hasConcept C162834538 @default.
• W1966168055 hasConcept C172680121 @default.
• W1966168055 hasConcept C203014093 @default.
• W1966168055 hasConcept C2779234561 @default.
• W1966168055 hasConcept C28328180 @default.
• W1966168055 hasConcept C54355233 @default.
• W1966168055 hasConcept C86803240 @default.
• W1966168055 hasConceptScore W1966168055C147483822 @default.
• W1966168055 hasConceptScore W1966168055C159047783 @default.
• W1966168055 hasConceptScore W1966168055C162834538 @default.
• W1966168055 hasConceptScore W1966168055C172680121 @default.
• W1966168055 hasConceptScore W1966168055C203014093 @default.
• W1966168055 hasConceptScore W1966168055C2779234561 @default.
• W1966168055 hasConceptScore W1966168055C28328180 @default.
• W1966168055 hasConceptScore W1966168055C54355233 @default.
• W1966168055 hasConceptScore W1966168055C86803240 @default.
• W1966168055 hasIssue "1" @default.
• W1966168055 hasLocation W19661680551 @default.
• W1966168055 hasLocation W19661680552 @default.
• W1966168055 hasLocation W19661680553 @default.
• W1966168055 hasOpenAccess W1966168055 @default.
• W1966168055 hasPrimaryLocation W19661680551 @default.
• W1966168055 hasRelatedWork W1702322095 @default.
• W1966168055 hasRelatedWork W1865764402 @default.
• W1966168055 hasRelatedWork W1975114493 @default.
• W1966168055 hasRelatedWork W2023370075 @default.
• W1966168055 hasRelatedWork W2087046172 @default.
• W1966168055 hasRelatedWork W2113382995 @default.
• W1966168055 hasRelatedWork W2113906287 @default.
• W1966168055 hasRelatedWork W2118087741 @default.
• W1966168055 hasRelatedWork W2321731952 @default.
• W1966168055 hasRelatedWork W3029386773 @default.
• W1966168055 hasVolume "1" @default.
• W1966168055 isParatext "false" @default.
• W1966168055 isRetracted "false" @default.
• W1966168055 magId "1966168055" @default.
• W1966168055 workType "article" @default.