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• W1966169120 startingPage "6025" @default.
• W1966169120 abstract "The gene VII protein (pVII) and gene IX protein (pIX) are associated closely on the surface of filamentous bacteriophage that is opposite of the end harboring the widely exploited pIII protein. We developed a phagemid format wherein antibody heavy- and light-chain variable regions were fused to the amino termini of pVII and pIX, respectively. Significantly, the fusion proteins interacted to form a functional Fv-binding domain on the phage surface. Our approach will be applicable to the display of generic peptide and protein libraries that can form combinatorial heterodimeric arrays. Consequently, it represents a first step toward artificial antibodies and the selection of novel biological activities." @default.
• W1966169120 created "2016-06-24" @default.
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• W1966169120 date "1999-05-25" @default.
• W1966169120 modified "2023-10-10" @default.
• W1966169120 title "Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays" @default.
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• W1966169120 doi "https://doi.org/10.1073/pnas.96.11.6025" @default.
• W1966169120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26829" @default.
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