Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966171520> ?p ?o ?g. }
- W1966171520 endingPage "e969" @default.
- W1966171520 startingPage "e969" @default.
- W1966171520 abstract "Abstract Platelets enhance thrombin generation at sites of vascular injury by exposing phosphatidylserine during necrosis-like cell death. Anoctamin 6 (Ano6) is required for Ca 2+ -dependent phosphatidylserine exposure and is defective in patients with Scott syndrome, a rare bleeding disorder. Ano6 may also form Cl − channels, though the role of Cl − fluxes in platelet procoagulant activity has not been explored. We found that Cl − channel blockers or removal of extracellular Cl − inhibited agonist-induced phosphatidylserine exposure. However, this was not due to direct inhibition of Ca 2+ -dependent scrambling since Ca 2+ ionophore-induced phosphatidylserine exposure was normal. This implies that the role of Ano6 in Ca 2+− dependent PS exposure is likely to differ from any putative function of Ano6 as a Cl − channel. Instead, Cl − channel blockade inhibited agonist-induced Ca 2+ entry. Importantly, Cl − channel blockers also prevented agonist-induced membrane hyperpolarization, resulting in depolarization. We propose that Cl − entry through Cl − channels is required for this hyperpolarization, maintaining the driving force for Ca 2+ entry and triggering full phosphatidylserine exposure. This demonstrates a novel role for Cl − channels in controlling platelet death and procoagulant activity." @default.
- W1966171520 created "2016-06-24" @default.
- W1966171520 creator A5035254895 @default.
- W1966171520 creator A5051674131 @default.
- W1966171520 date "2013-12-19" @default.
- W1966171520 modified "2023-10-08" @default.
- W1966171520 title "Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity" @default.
- W1966171520 cites W1572656115 @default.
- W1966171520 cites W1587254203 @default.
- W1966171520 cites W1837090086 @default.
- W1966171520 cites W1967510354 @default.
- W1966171520 cites W1968188734 @default.
- W1966171520 cites W2000178601 @default.
- W1966171520 cites W2017197907 @default.
- W1966171520 cites W2025166330 @default.
- W1966171520 cites W2055981402 @default.
- W1966171520 cites W2057200599 @default.
- W1966171520 cites W2065417952 @default.
- W1966171520 cites W2077263250 @default.
- W1966171520 cites W2080672743 @default.
- W1966171520 cites W2086589360 @default.
- W1966171520 cites W2087806872 @default.
- W1966171520 cites W2091401363 @default.
- W1966171520 cites W2091437674 @default.
- W1966171520 cites W2093709619 @default.
- W1966171520 cites W2095049732 @default.
- W1966171520 cites W2120791372 @default.
- W1966171520 cites W2141260882 @default.
- W1966171520 cites W2156294657 @default.
- W1966171520 cites W2156638209 @default.
- W1966171520 cites W2163789582 @default.
- W1966171520 cites W40591220 @default.
- W1966171520 cites W4247741685 @default.
- W1966171520 doi "https://doi.org/10.1038/cddis.2013.495" @default.
- W1966171520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3877565" @default.
- W1966171520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24357800" @default.
- W1966171520 hasPublicationYear "2013" @default.
- W1966171520 type Work @default.
- W1966171520 sameAs 1966171520 @default.
- W1966171520 citedByCount "46" @default.
- W1966171520 countsByYear W19661715202014 @default.
- W1966171520 countsByYear W19661715202015 @default.
- W1966171520 countsByYear W19661715202016 @default.
- W1966171520 countsByYear W19661715202017 @default.
- W1966171520 countsByYear W19661715202018 @default.
- W1966171520 countsByYear W19661715202019 @default.
- W1966171520 countsByYear W19661715202020 @default.
- W1966171520 countsByYear W19661715202021 @default.
- W1966171520 countsByYear W19661715202022 @default.
- W1966171520 countsByYear W19661715202023 @default.
- W1966171520 crossrefType "journal-article" @default.
- W1966171520 hasAuthorship W1966171520A5035254895 @default.
- W1966171520 hasAuthorship W1966171520A5051674131 @default.
- W1966171520 hasBestOaLocation W19661715201 @default.
- W1966171520 hasConcept C12554922 @default.
- W1966171520 hasConcept C126322002 @default.
- W1966171520 hasConcept C131453863 @default.
- W1966171520 hasConcept C134018914 @default.
- W1966171520 hasConcept C145822097 @default.
- W1966171520 hasConcept C170493617 @default.
- W1966171520 hasConcept C181911157 @default.
- W1966171520 hasConcept C185592680 @default.
- W1966171520 hasConcept C188810444 @default.
- W1966171520 hasConcept C2777292125 @default.
- W1966171520 hasConcept C2778918659 @default.
- W1966171520 hasConcept C2778938600 @default.
- W1966171520 hasConcept C2779637612 @default.
- W1966171520 hasConcept C28406088 @default.
- W1966171520 hasConcept C4141045 @default.
- W1966171520 hasConcept C41625074 @default.
- W1966171520 hasConcept C55493867 @default.
- W1966171520 hasConcept C66974803 @default.
- W1966171520 hasConcept C71240020 @default.
- W1966171520 hasConcept C71924100 @default.
- W1966171520 hasConcept C83743174 @default.
- W1966171520 hasConcept C86803240 @default.
- W1966171520 hasConcept C89560881 @default.
- W1966171520 hasConcept C95444343 @default.
- W1966171520 hasConcept C98274493 @default.
- W1966171520 hasConceptScore W1966171520C12554922 @default.
- W1966171520 hasConceptScore W1966171520C126322002 @default.
- W1966171520 hasConceptScore W1966171520C131453863 @default.
- W1966171520 hasConceptScore W1966171520C134018914 @default.
- W1966171520 hasConceptScore W1966171520C145822097 @default.
- W1966171520 hasConceptScore W1966171520C170493617 @default.
- W1966171520 hasConceptScore W1966171520C181911157 @default.
- W1966171520 hasConceptScore W1966171520C185592680 @default.
- W1966171520 hasConceptScore W1966171520C188810444 @default.
- W1966171520 hasConceptScore W1966171520C2777292125 @default.
- W1966171520 hasConceptScore W1966171520C2778918659 @default.
- W1966171520 hasConceptScore W1966171520C2778938600 @default.
- W1966171520 hasConceptScore W1966171520C2779637612 @default.
- W1966171520 hasConceptScore W1966171520C28406088 @default.
- W1966171520 hasConceptScore W1966171520C4141045 @default.
- W1966171520 hasConceptScore W1966171520C41625074 @default.
- W1966171520 hasConceptScore W1966171520C55493867 @default.
- W1966171520 hasConceptScore W1966171520C66974803 @default.
- W1966171520 hasConceptScore W1966171520C71240020 @default.