FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966171672> ?p ?o ?g. }

• W1966171672 endingPage "731" @default.
• W1966171672 startingPage "726" @default.
• W1966171672 abstract "The polymorphic nature of sequences which act as retinoic acid response elements (RAREs and RXREs) in transactivation assays in mammalian cells, suggests that elements consisting of a direct repetition of a half site motif, separated by 1 to 5 base pairs (DR1 to DR5), are targets for retinoic acid (RA) signalling. In a previous report we showed that in yeast cells, heterodimers of the retinoic acid receptors RAR alpha and RXR alpha were required for efficient transcription of a reporter gene containing a DR5 element [Heery et al., (1993); Proc. Natl. Acad. Sci. USA, 90: 4281-4285]. Here we report that DR1 to DR5 elements containing a direct repeat of the 5'-AGGTCA-3' motif, and an inverted repeat of the same sequence with no spacer (IR0), behave as RAREs in yeast cells coexpressing RAR alpha and RXR alpha, albeit with different efficacies. Heterodimer activity was strongest on a DR5 reporter gene, and the strength of activation of the reporter series (DR5 > DR1 > DR3 > DR2 = IR0 = DR4) correlated with the ability of the heterodimer to bind to the corresponding sequences in vitro. Significantly, a reporter containing a DR1 element was selectively and efficiently activated in yeast cells expressing only RXR alpha. This activity was dependent on the induction by 9-cis retinoic acid of an activation function (AF-2) located in the RXR alpha ligand binding domain. In addition, a strong synergistic activity of RXR alpha was observed on a reporter containing the putative RXR element (RXRE) from the rat CRBPII gene promoter. Thus, RXR alpha can function independently as a transcription factor, in the absence of RARs or other heteromeric partners. Similarly, homodimers of RAR alpha selectively stimulated the transcription of a DR5 reporter in a ligand-dependent manner, but less efficiently than RAR alpha/RXR alpha heterodimers." @default.
• W1966171672 created "2016-06-24" @default.
• W1966171672 creator A5011999580 @default.
• W1966171672 creator A5024492052 @default.
• W1966171672 creator A5044999679 @default.
• W1966171672 creator A5085761422 @default.
• W1966171672 creator A5090678712 @default.
• W1966171672 date "1994-01-01" @default.
• W1966171672 modified "2023-09-27" @default.
• W1966171672 title "Homo- and heterodimers of the retinoid X receptor (RXR) activate transcription in yeast" @default.
• W1966171672 cites W129841773 @default.
• W1966171672 cites W1578055894 @default.
• W1966171672 cites W1587588231 @default.
• W1966171672 cites W1589475164 @default.
• W1966171672 cites W1595664534 @default.
• W1966171672 cites W1597303911 @default.
• W1966171672 cites W1814235153 @default.
• W1966171672 cites W1896511711 @default.
• W1966171672 cites W1898196512 @default.
• W1966171672 cites W1964300769 @default.
• W1966171672 cites W1970473343 @default.
• W1966171672 cites W1984509210 @default.
• W1966171672 cites W1987040411 @default.
• W1966171672 cites W1987269203 @default.
• W1966171672 cites W1997473658 @default.
• W1966171672 cites W1997514802 @default.
• W1966171672 cites W2002529271 @default.
• W1966171672 cites W2006985642 @default.
• W1966171672 cites W2012761399 @default.
• W1966171672 cites W2024082124 @default.
• W1966171672 cites W2032096382 @default.
• W1966171672 cites W2039603232 @default.
• W1966171672 cites W2041270901 @default.
• W1966171672 cites W2051663421 @default.
• W1966171672 cites W2074786828 @default.
• W1966171672 cites W2085124463 @default.
• W1966171672 cites W2091735624 @default.
• W1966171672 cites W2097616503 @default.
• W1966171672 cites W2102082802 @default.
• W1966171672 cites W2105268520 @default.
• W1966171672 cites W2112823160 @default.
• W1966171672 cites W2120176836 @default.
• W1966171672 cites W2148897170 @default.
• W1966171672 cites W2163612441 @default.
• W1966171672 cites W2169333620 @default.
• W1966171672 cites W2180559065 @default.
• W1966171672 cites W2253880684 @default.
• W1966171672 cites W2410727204 @default.
• W1966171672 doi "https://doi.org/10.1093/nar/22.5.726" @default.
• W1966171672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/307875" @default.
• W1966171672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8139911" @default.
• W1966171672 hasPublicationYear "1994" @default.
• W1966171672 type Work @default.
• W1966171672 sameAs 1966171672 @default.
• W1966171672 citedByCount "54" @default.
• W1966171672 countsByYear W19661716722012 @default.
• W1966171672 countsByYear W19661716722013 @default.
• W1966171672 countsByYear W19661716722014 @default.
• W1966171672 countsByYear W19661716722015 @default.
• W1966171672 countsByYear W19661716722020 @default.
• W1966171672 countsByYear W19661716722021 @default.
• W1966171672 crossrefType "journal-article" @default.
• W1966171672 hasAuthorship W1966171672A5011999580 @default.
• W1966171672 hasAuthorship W1966171672A5024492052 @default.
• W1966171672 hasAuthorship W1966171672A5044999679 @default.
• W1966171672 hasAuthorship W1966171672A5085761422 @default.
• W1966171672 hasAuthorship W1966171672A5090678712 @default.
• W1966171672 hasBestOaLocation W19661716723 @default.
• W1966171672 hasConcept C101762097 @default.
• W1966171672 hasConcept C104317684 @default.
• W1966171672 hasConcept C120197328 @default.
• W1966171672 hasConcept C128821507 @default.
• W1966171672 hasConcept C1292079 @default.
• W1966171672 hasConcept C132376346 @default.
• W1966171672 hasConcept C138885662 @default.
• W1966171672 hasConcept C150194340 @default.
• W1966171672 hasConcept C153911025 @default.
• W1966171672 hasConcept C161733203 @default.
• W1966171672 hasConcept C179926584 @default.
• W1966171672 hasConcept C2781121885 @default.
• W1966171672 hasConcept C41895202 @default.
• W1966171672 hasConcept C55493867 @default.
• W1966171672 hasConcept C63932345 @default.
• W1966171672 hasConcept C86339819 @default.
• W1966171672 hasConcept C86803240 @default.
• W1966171672 hasConceptScore W1966171672C101762097 @default.
• W1966171672 hasConceptScore W1966171672C104317684 @default.
• W1966171672 hasConceptScore W1966171672C120197328 @default.
• W1966171672 hasConceptScore W1966171672C128821507 @default.
• W1966171672 hasConceptScore W1966171672C1292079 @default.
• W1966171672 hasConceptScore W1966171672C132376346 @default.
• W1966171672 hasConceptScore W1966171672C138885662 @default.
• W1966171672 hasConceptScore W1966171672C150194340 @default.
• W1966171672 hasConceptScore W1966171672C153911025 @default.
• W1966171672 hasConceptScore W1966171672C161733203 @default.
• W1966171672 hasConceptScore W1966171672C179926584 @default.
• W1966171672 hasConceptScore W1966171672C2781121885 @default.
• W1966171672 hasConceptScore W1966171672C41895202 @default.

• next