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- W1966173885 abstract "Diabetes mellitus and bilateral optic atrophy are the defining characteristics of the autosomal recessive Wolfram syndrome. Diabetes insipidus, neurogenic bladder, deafness, and other neurological manifestations are frequent. A review was made of the medical records of 68 Wolfram syndrome patients, aged between 8 and 43 years, identified by casefinding throughout the USA. 41 of the patients (60%) had episodes of severe depression, psychosis, or organic brain syndrome, as well as impulsive verbal and physical aggression. These symptoms were very severe in 17 patients (25%), of whom 12 required admission to a psychiatric hospital and 11 attempted suicide. We conclude that the Wolfram syndrome gene predisposes homozygotes to psychiatric illness." @default.
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- W1966173885 date "1990-09-01" @default.
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- W1966173885 title "Psychiatric findings in Wolfram syndrome homozygotes" @default.
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- W1966173885 doi "https://doi.org/10.1016/0140-6736(90)92157-d" @default.
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