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- W1966174134 abstract "Lipid droplets (LDs), initially considered inert lipid deposits, have gained during the last decade the classification of cytosolic organelles due to their defined composition and the multiplicity of specific cellular functions in which they are involved. The classification of LD as organelles brings along the need for their regulated turnover and recent findings support the direct contribution of autophagy to this turnover through a process now described as lipophagy. This paper focuses on the characteristics of this new type of selective autophagy and the cellular consequences of the mobilization of intracellular lipids through this process. Lipophagy impacts the cellular energetic balance directly, through lipid breakdown and, indirectly, by regulating food intake. Defective lipophagy has been already linked to important metabolic disorders such as fatty liver, obesity and atherosclerosis, and the age-dependent decrease in autophagy could underline the basis for the metabolic syndrome of aging." @default.
- W1966174134 created "2016-06-24" @default.
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- W1966174134 date "2012-01-01" @default.
- W1966174134 modified "2023-10-15" @default.
- W1966174134 title "Lipophagy: Connecting Autophagy and Lipid Metabolism" @default.
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- W1966174134 doi "https://doi.org/10.1155/2012/282041" @default.
- W1966174134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3320019" @default.
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