Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966174760> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1966174760 endingPage "196" @default.
- W1966174760 startingPage "185" @default.
- W1966174760 abstract "Tenascin-C (TN-C), an extracellular matrix glycoprotein, is crucial to cell-migration, proliferation, apoptosis and remodeling of tissues, with a potential role in pathobiology of pulmonary hypertension. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial to the integrity of the extracellular matrix. TN-C and MMPs are counter-regulatory molecules, which influence the vascular integrity through modulations of elastin. We have a murine model of pulmonary hypoplasia with coexistent diaphragmatic hernia, vascular abnormalities and excessive arterial smooth muscle cell (SMC) proliferation.Our objective was to investigate modulations of TN-C and MMPs in hypoplastic lungs and their possible contribution to the observed pulmonary vascular abnormalities.We addressed our objectives by pursing immunoblotting and immunohistochemistry and zymography/reverse zymography to assess the alterations in activities of MMPs and their inhibitors.We observed significant down-regulation of MMP-9 activity in hypoplastic lungs at the later fetal developmental stages, whereas MMP-2 activity assessed by gelatin zymography remained unaltered. Reverse zymography revealed up-regulation of activities of TIMP-1, -2, -3 and -4 in hypoplastic lungs during later fetal development, with pronounced increases in TIMP-3 and -4 activities. Furthermore, immunoblot analyses and immunohistochemistry revealed that TN-C protein was down-regulated in developing hypoplastic lungs, compared to normal lungs.(1)TN-C is known to inhibit vascular SMC proliferation. But, decrease in TN-C in hypoplastic lungs may support the observed arterial SMC proliferation. (2) Our studies showed that in hypoplastic lungs the SMC apoptosis is not affected, thus suggesting that SMC proliferation and apoptosis may be two separate processes in pulmonary hypoplasia with coexistent diaphragmatic hernia. Together, our data showed an imbalance in the extracellular matrix proteins, which may contribute to the pulmonary vascular abnormalities." @default.
- W1966174760 created "2016-06-24" @default.
- W1966174760 creator A5016583022 @default.
- W1966174760 creator A5076075519 @default.
- W1966174760 date "2006-01-01" @default.
- W1966174760 modified "2023-10-16" @default.
- W1966174760 title "Relevance of Tenascin-C and Matrix Metalloproteinases in Vascular Abnormalities in Murine Hypoplastic Lungs" @default.
- W1966174760 cites W1546619202 @default.
- W1966174760 cites W1950892959 @default.
- W1966174760 cites W1969966383 @default.
- W1966174760 cites W1982365221 @default.
- W1966174760 cites W1986923605 @default.
- W1966174760 cites W2042419096 @default.
- W1966174760 cites W2061223357 @default.
- W1966174760 cites W2071596110 @default.
- W1966174760 cites W2089304754 @default.
- W1966174760 cites W2095571954 @default.
- W1966174760 cites W2098954233 @default.
- W1966174760 cites W2107572053 @default.
- W1966174760 cites W2109197670 @default.
- W1966174760 cites W2111723790 @default.
- W1966174760 cites W2121242925 @default.
- W1966174760 cites W2128635872 @default.
- W1966174760 cites W2147660741 @default.
- W1966174760 cites W2154522740 @default.
- W1966174760 cites W2162908585 @default.
- W1966174760 cites W2167709602 @default.
- W1966174760 cites W2186281877 @default.
- W1966174760 cites W2315819183 @default.
- W1966174760 cites W2401148185 @default.
- W1966174760 cites W2404271118 @default.
- W1966174760 cites W4250908540 @default.
- W1966174760 doi "https://doi.org/10.1159/000093308" @default.
- W1966174760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16699260" @default.
- W1966174760 hasPublicationYear "2006" @default.
- W1966174760 type Work @default.
- W1966174760 sameAs 1966174760 @default.
- W1966174760 citedByCount "9" @default.
- W1966174760 countsByYear W19661747602013 @default.
- W1966174760 countsByYear W19661747602014 @default.
- W1966174760 countsByYear W19661747602015 @default.
- W1966174760 countsByYear W19661747602022 @default.
- W1966174760 crossrefType "journal-article" @default.
- W1966174760 hasAuthorship W1966174760A5016583022 @default.
- W1966174760 hasAuthorship W1966174760A5076075519 @default.
- W1966174760 hasConcept C109523444 @default.
- W1966174760 hasConcept C117961784 @default.
- W1966174760 hasConcept C142724271 @default.
- W1966174760 hasConcept C177430391 @default.
- W1966174760 hasConcept C189165786 @default.
- W1966174760 hasConcept C204232928 @default.
- W1966174760 hasConcept C2777738151 @default.
- W1966174760 hasConcept C2779869378 @default.
- W1966174760 hasConcept C55493867 @default.
- W1966174760 hasConcept C71924100 @default.
- W1966174760 hasConcept C86492073 @default.
- W1966174760 hasConcept C86803240 @default.
- W1966174760 hasConcept C95444343 @default.
- W1966174760 hasConceptScore W1966174760C109523444 @default.
- W1966174760 hasConceptScore W1966174760C117961784 @default.
- W1966174760 hasConceptScore W1966174760C142724271 @default.
- W1966174760 hasConceptScore W1966174760C177430391 @default.
- W1966174760 hasConceptScore W1966174760C189165786 @default.
- W1966174760 hasConceptScore W1966174760C204232928 @default.
- W1966174760 hasConceptScore W1966174760C2777738151 @default.
- W1966174760 hasConceptScore W1966174760C2779869378 @default.
- W1966174760 hasConceptScore W1966174760C55493867 @default.
- W1966174760 hasConceptScore W1966174760C71924100 @default.
- W1966174760 hasConceptScore W1966174760C86492073 @default.
- W1966174760 hasConceptScore W1966174760C86803240 @default.
- W1966174760 hasConceptScore W1966174760C95444343 @default.
- W1966174760 hasIssue "3" @default.
- W1966174760 hasLocation W19661747601 @default.
- W1966174760 hasLocation W19661747602 @default.
- W1966174760 hasOpenAccess W1966174760 @default.
- W1966174760 hasPrimaryLocation W19661747601 @default.
- W1966174760 hasRelatedWork W2020598461 @default.
- W1966174760 hasRelatedWork W2060452165 @default.
- W1966174760 hasRelatedWork W2111522129 @default.
- W1966174760 hasRelatedWork W2122706185 @default.
- W1966174760 hasRelatedWork W2159546582 @default.
- W1966174760 hasRelatedWork W2747882396 @default.
- W1966174760 hasRelatedWork W2793564284 @default.
- W1966174760 hasRelatedWork W2799755331 @default.
- W1966174760 hasRelatedWork W4242915321 @default.
- W1966174760 hasRelatedWork W67680274 @default.
- W1966174760 hasVolume "90" @default.
- W1966174760 isParatext "false" @default.
- W1966174760 isRetracted "false" @default.
- W1966174760 magId "1966174760" @default.
- W1966174760 workType "article" @default.