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- W1966174906 abstract "Abstract Microscopic examination of primitive-line erythroblasts in the chick embryo shows an apparent progressive increase in amount of condensed chromatin in the nuclei during development. Quantitative estimates of condensed chromatin using both tracing and weighing and stereological point-counting of areas in electron microscope profiles indicates, however, that this is a misleading illusion. The volume of condensed chromatin in proerythroblasts of the 1.5 day embryo is already high and making allowance for chromosome replication in the earlier stages there appears to be no major change in the volume of condensed chromatin during development beyond proerythroblast or early polychromatophilic erythroblast. There is no major change in the density of packing of chromatin fibrils in the condensed chromatin of nuclei from the early polychromatophilic stage to maturity. The main nuclear changes which do take place during development are a decrease in the volume of nuclear regions between condensed chromatin (areas occupied by the nucleolus and dispersed chromatin) and a concomitant decrease in overall nuclear volume. These changes lead to a progressive aggregation of the condensed chromatin into large, increasingly obvious clumps. It is proposed that much of the chromatin of the erythrocyte is condensed as a very early part of its development and cell differentiation presumably depends on genetic activity of a relatively small amount of dispersed chromatin regulated in an unknown way." @default.
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- W1966174906 date "1976-06-01" @default.
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- W1966174906 title "Volume of condensed chromatin in developing primitive-line erythrocytes of chick" @default.
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- W1966174906 doi "https://doi.org/10.1016/0014-4827(76)90338-4" @default.
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