FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966176408> ?p ?o ?g. }

• W1966176408 endingPage "152" @default.
• W1966176408 startingPage "144" @default.
• W1966176408 abstract "Photoactivated hypericin produces singlet oxygen and superoxide anion radical; however, the intracellular events contributing to toxicity are unknown. Clonogenic assays of oxygen-dependent hypericin phototoxicity to EMT6 cells have previously shown that 0.5 μM hypericin + 1.5 J cm−2 fluorescent light is non-toxic and that 1.0 μM hypericin + 1.5 J cm−2 fluorescent light produces LD40 toxicity. Intracellular events leading to toxicity were revealed at these doses. Lactate dehydrogenase leakage was elevated for both 0.5 μM and 1.0 μM hypericin + light immediately following irradiation. While values eventually returned to control levels for 0.5 μM hypericin + light, leakage increased over time for 1.0 μM hypericin indicating reversible and irreversible toxicity, respectively. Increases in lipid and protein oxidation were measured immediately following irradiation; however, these parameters return to control levels within 0.5 h for both doses. Both total cellular ATP levels and cellular respiration were depressed by approximately 50% of control values for 1.0 μM hypericin + light. These values were unchanged for 0.5 μM hypericin + light. Along with previously reported data demonstrating that light-activated hypericin can inhibit mitochondial succinoxidase in beef heart mitochondria in vitro, these data support oxidative stress-initiated mitochondrial damage as a key target in hypericin phototoxicity." @default.
• W1966176408 created "2016-06-24" @default.
• W1966176408 creator A5002357025 @default.
• W1966176408 creator A5058807269 @default.
• W1966176408 creator A5067930144 @default.
• W1966176408 date "1998-07-01" @default.
• W1966176408 modified "2023-10-03" @default.
• W1966176408 title "Time-Course of Hypericin Phototoxicity and Effect on Mitochondrial Energies in EMT6 Mouse Mammary Carcinoma Cells" @default.
• W1966176408 cites W1567614586 @default.
• W1966176408 cites W1968955935 @default.
• W1966176408 cites W1988354017 @default.
• W1966176408 cites W2018272990 @default.
• W1966176408 cites W2029114201 @default.
• W1966176408 cites W2029808613 @default.
• W1966176408 cites W2032520138 @default.
• W1966176408 cites W2042661067 @default.
• W1966176408 cites W2042918517 @default.
• W1966176408 cites W2059648520 @default.
• W1966176408 cites W2090749980 @default.
• W1966176408 cites W2092600413 @default.
• W1966176408 cites W2110413467 @default.
• W1966176408 cites W2130250535 @default.
• W1966176408 cites W2159689159 @default.
• W1966176408 cites W2499505205 @default.
• W1966176408 cites W2503618025 @default.
• W1966176408 cites W969915667 @default.
• W1966176408 doi "https://doi.org/10.1016/s0891-5849(98)00052-5" @default.
• W1966176408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9667489" @default.
• W1966176408 hasPublicationYear "1998" @default.
• W1966176408 type Work @default.
• W1966176408 sameAs 1966176408 @default.
• W1966176408 citedByCount "24" @default.
• W1966176408 countsByYear W19661764082012 @default.
• W1966176408 countsByYear W19661764082014 @default.
• W1966176408 countsByYear W19661764082015 @default.
• W1966176408 countsByYear W19661764082016 @default.
• W1966176408 countsByYear W19661764082018 @default.
• W1966176408 countsByYear W19661764082020 @default.
• W1966176408 countsByYear W19661764082023 @default.
• W1966176408 crossrefType "journal-article" @default.
• W1966176408 hasAuthorship W1966176408A5002357025 @default.
• W1966176408 hasAuthorship W1966176408A5058807269 @default.
• W1966176408 hasAuthorship W1966176408A5067930144 @default.
• W1966176408 hasConcept C12554922 @default.
• W1966176408 hasConcept C178790620 @default.
• W1966176408 hasConcept C181199279 @default.
• W1966176408 hasConcept C185592680 @default.
• W1966176408 hasConcept C202751555 @default.
• W1966176408 hasConcept C20639190 @default.
• W1966176408 hasConcept C2776151105 @default.
• W1966176408 hasConcept C2778432610 @default.
• W1966176408 hasConcept C2780795997 @default.
• W1966176408 hasConcept C2781323092 @default.
• W1966176408 hasConcept C2781469039 @default.
• W1966176408 hasConcept C29730261 @default.
• W1966176408 hasConcept C48349386 @default.
• W1966176408 hasConcept C55493867 @default.
• W1966176408 hasConcept C75473681 @default.
• W1966176408 hasConcept C79879829 @default.
• W1966176408 hasConcept C86803240 @default.
• W1966176408 hasConcept C98274493 @default.
• W1966176408 hasConceptScore W1966176408C12554922 @default.
• W1966176408 hasConceptScore W1966176408C178790620 @default.
• W1966176408 hasConceptScore W1966176408C181199279 @default.
• W1966176408 hasConceptScore W1966176408C185592680 @default.
• W1966176408 hasConceptScore W1966176408C202751555 @default.
• W1966176408 hasConceptScore W1966176408C20639190 @default.
• W1966176408 hasConceptScore W1966176408C2776151105 @default.
• W1966176408 hasConceptScore W1966176408C2778432610 @default.
• W1966176408 hasConceptScore W1966176408C2780795997 @default.
• W1966176408 hasConceptScore W1966176408C2781323092 @default.
• W1966176408 hasConceptScore W1966176408C2781469039 @default.
• W1966176408 hasConceptScore W1966176408C29730261 @default.
• W1966176408 hasConceptScore W1966176408C48349386 @default.
• W1966176408 hasConceptScore W1966176408C55493867 @default.
• W1966176408 hasConceptScore W1966176408C75473681 @default.
• W1966176408 hasConceptScore W1966176408C79879829 @default.
• W1966176408 hasConceptScore W1966176408C86803240 @default.
• W1966176408 hasConceptScore W1966176408C98274493 @default.
• W1966176408 hasIssue "2" @default.
• W1966176408 hasLocation W19661764081 @default.
• W1966176408 hasLocation W19661764082 @default.
• W1966176408 hasOpenAccess W1966176408 @default.
• W1966176408 hasPrimaryLocation W19661764081 @default.
• W1966176408 hasRelatedWork W137680134 @default.
• W1966176408 hasRelatedWork W1536041849 @default.
• W1966176408 hasRelatedWork W1972430154 @default.
• W1966176408 hasRelatedWork W2009039194 @default.
• W1966176408 hasRelatedWork W2087426457 @default.
• W1966176408 hasRelatedWork W2122126311 @default.
• W1966176408 hasRelatedWork W2910704098 @default.
• W1966176408 hasRelatedWork W3016578306 @default.
• W1966176408 hasRelatedWork W3026717167 @default.
• W1966176408 hasRelatedWork W3165846024 @default.
• W1966176408 hasVolume "25" @default.
• W1966176408 isParatext "false" @default.
• W1966176408 isRetracted "false" @default.
• W1966176408 magId "1966176408" @default.

• next