FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966180364> ?p ?o ?g. }

• W1966180364 endingPage "284" @default.
• W1966180364 startingPage "275" @default.
• W1966180364 abstract "Adrenal steroid hormones are capable of interfering with a variety of behavioral phenomena including sleep. The mechanisms appear to involve effects at the cell membrane as well as nuclear actions mediated by intracellular mineralo- and glucocorticosteroid receptors (MR and GR). We employed the MR agonist deoxycorticosterone (DOC) and the MR antagonist spironolactone (SP) to study the role of MRs in the regulation of human sleep. We also tested whether the effects of DOC upon the sleep EEG and nocturnal hormone secretion (growth hormone and cortisol) are compatible with those predicted for its major metabolite tetrahydro-DOC (THDOC): electrophysiological and animal experiments had suggested that THDOC would act as a hypnotic via positive modulation of the GABAA receptor. Because neither DOC nor SP affected the sleep EEG substantially, the involvement of MRs in the regulation of sleep needs further study. The sleep-endocrine data showed a suppressive effect of DOC upon plasma cortisol concentrations and an earlier occurrence of nocturnal GH maxima, which can be plausibly explained by GR or sigma receptor-mediated effects. Molecular characterization of DOC and SP confirmed a relatively strong effect of DOC upon transactivation via MR and no effect of SP on the GR-mediated transcription rate. In addition, the possibility that a low dose of the mineralocorticoid DOC may serve as a prodrug for the potential hypnotic THDOC is not supported by the current data." @default.
• W1966180364 created "2016-06-24" @default.
• W1966180364 creator A5010209530 @default.
• W1966180364 creator A5024620719 @default.
• W1966180364 creator A5044329719 @default.
• W1966180364 creator A5048419237 @default.
• W1966180364 creator A5048617845 @default.
• W1966180364 creator A5062489125 @default.
• W1966180364 creator A5083339355 @default.
• W1966180364 creator A5084861346 @default.
• W1966180364 date "1993-07-01" @default.
• W1966180364 modified "2023-10-17" @default.
• W1966180364 title "Functional properties of deoxycorticosterone and spironolactone: Molecular characterization and effects on sleep-endocrine activity" @default.
• W1966180364 cites W1968544967 @default.
• W1966180364 cites W1970468270 @default.
• W1966180364 cites W1972446610 @default.
• W1966180364 cites W1998236920 @default.
• W1966180364 cites W2003532781 @default.
• W1966180364 cites W2004298645 @default.
• W1966180364 cites W2005914718 @default.
• W1966180364 cites W2006442321 @default.
• W1966180364 cites W2007135601 @default.
• W1966180364 cites W2015497140 @default.
• W1966180364 cites W2024344189 @default.
• W1966180364 cites W2027593853 @default.
• W1966180364 cites W2040727780 @default.
• W1966180364 cites W2050061211 @default.
• W1966180364 cites W2051319927 @default.
• W1966180364 cites W2051585413 @default.
• W1966180364 cites W2056799965 @default.
• W1966180364 cites W2061386704 @default.
• W1966180364 cites W2074802748 @default.
• W1966180364 cites W2083447043 @default.
• W1966180364 cites W2088622701 @default.
• W1966180364 cites W2097794242 @default.
• W1966180364 cites W2097964700 @default.
• W1966180364 cites W2129972061 @default.
• W1966180364 cites W2133753087 @default.
• W1966180364 cites W2145594744 @default.
• W1966180364 cites W4240006245 @default.
• W1966180364 cites W4245117662 @default.
• W1966180364 cites W4254779090 @default.
• W1966180364 doi "https://doi.org/10.1016/0022-3956(93)90038-4" @default.
• W1966180364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8295159" @default.
• W1966180364 hasPublicationYear "1993" @default.
• W1966180364 type Work @default.
• W1966180364 sameAs 1966180364 @default.
• W1966180364 citedByCount "28" @default.
• W1966180364 countsByYear W19661803642012 @default.
• W1966180364 countsByYear W19661803642014 @default.
• W1966180364 countsByYear W19661803642015 @default.
• W1966180364 countsByYear W19661803642019 @default.
• W1966180364 countsByYear W19661803642020 @default.
• W1966180364 countsByYear W19661803642023 @default.
• W1966180364 crossrefType "journal-article" @default.
• W1966180364 hasAuthorship W1966180364A5010209530 @default.
• W1966180364 hasAuthorship W1966180364A5024620719 @default.
• W1966180364 hasAuthorship W1966180364A5044329719 @default.
• W1966180364 hasAuthorship W1966180364A5048419237 @default.
• W1966180364 hasAuthorship W1966180364A5048617845 @default.
• W1966180364 hasAuthorship W1966180364A5062489125 @default.
• W1966180364 hasAuthorship W1966180364A5083339355 @default.
• W1966180364 hasAuthorship W1966180364A5084861346 @default.
• W1966180364 hasConcept C126322002 @default.
• W1966180364 hasConcept C134018914 @default.
• W1966180364 hasConcept C170493617 @default.
• W1966180364 hasConcept C185592680 @default.
• W1966180364 hasConcept C189135053 @default.
• W1966180364 hasConcept C2776069600 @default.
• W1966180364 hasConcept C2778525890 @default.
• W1966180364 hasConcept C2778938600 @default.
• W1966180364 hasConcept C71924100 @default.
• W1966180364 hasConcept C86803240 @default.
• W1966180364 hasConcept C98274493 @default.
• W1966180364 hasConceptScore W1966180364C126322002 @default.
• W1966180364 hasConceptScore W1966180364C134018914 @default.
• W1966180364 hasConceptScore W1966180364C170493617 @default.
• W1966180364 hasConceptScore W1966180364C185592680 @default.
• W1966180364 hasConceptScore W1966180364C189135053 @default.
• W1966180364 hasConceptScore W1966180364C2776069600 @default.
• W1966180364 hasConceptScore W1966180364C2778525890 @default.
• W1966180364 hasConceptScore W1966180364C2778938600 @default.
• W1966180364 hasConceptScore W1966180364C71924100 @default.
• W1966180364 hasConceptScore W1966180364C86803240 @default.
• W1966180364 hasConceptScore W1966180364C98274493 @default.
• W1966180364 hasIssue "3" @default.
• W1966180364 hasLocation W19661803641 @default.
• W1966180364 hasLocation W19661803642 @default.
• W1966180364 hasOpenAccess W1966180364 @default.
• W1966180364 hasPrimaryLocation W19661803641 @default.
• W1966180364 hasRelatedWork W1986937962 @default.
• W1966180364 hasRelatedWork W2023418293 @default.
• W1966180364 hasRelatedWork W2037408526 @default.
• W1966180364 hasRelatedWork W2105380188 @default.
• W1966180364 hasRelatedWork W2312942238 @default.
• W1966180364 hasRelatedWork W2322243425 @default.
• W1966180364 hasRelatedWork W2516746587 @default.
• W1966180364 hasRelatedWork W2530319271 @default.

• next