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• W1966183610 abstract "Fructose-1,6-bisphosphatase (FBPase) is a key regulatory enzyme of gluconeogenesis. In the yeast Saccharomyces cerevisiae, it is only expressed when cells are grown in medium with nonfermentable carbon sources. Addition of glucose to cells leads to inactivation of FBPase and degradation via the ubiquitin–proteasome system. Polyubiquitination of FBPase is carried out by the Gid complex, a multi-subunit ubiquitin ligase. Using tandem affinity purification and subsequent mass spectrometry we identified the Hsp70 chaperone Ssa1 as a novel interaction partner of FBPase. Studies with the temperature-sensitive mutant ssa1-45ts showed that Ssa1 is essential for polyubiquitination of FBPase by the Gid complex. Moreover, we show that degradation of an additional gluconeogenic enzyme, phosphoenolpyruvate carboxykinase, is also affected in ssa1-45ts cells demonstrating that Ssa1 plays a general role in elimination of gluconeogenic enzymes." @default.
• W1966183610 created "2016-06-24" @default.
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• W1966183610 date "2010-07-01" @default.
• W1966183610 modified "2023-09-26" @default.
• W1966183610 title "The Hsp70 chaperone Ssa1 is essential for catabolite induced degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase" @default.
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• W1966183610 doi "https://doi.org/10.1016/j.bbrc.2010.05.123" @default.
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