Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966184433> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1966184433 endingPage "7" @default.
- W1966184433 startingPage "3" @default.
- W1966184433 abstract "The pre-clinical development of moclobemide is an example of broad research combined with serendipity. Moclobemide was first hypothesized as being an antilipaemic or antibiotic, but the screenings were negative. The search for its antidepressant qualities, based on anticholinergic tests, also proved negative and moclobemide was then suspected of being an antipsychotic before its specific and reversible monoamine oxidase (MAO)-A inhibition qualities were detected. After the establishment of its lack of relevant interference with tyramine pressure response, clinical trials were launched in 1977. In the first stage, multiple, small open and double-blind studies were carried out. Two decisive, large, multicentre, double-blind studies were later performed in Latin America and Austria. Further trials have confirmed the broad antidepressant activity of reversible monoamine oxidase inhibitors (RIMA), which is not confined to any one subtype of depression and which show good tolerability and low toxicity. Since moclobemide has been available on the market, extensive meta-analyses of a large data set provided a series of methodological results: factor structure of the Hamilton Depression Scale (HAMD), optimal criteria of efficacy, predictors of response, onset of action for antidepressants and placebo." @default.
- W1966184433 created "2016-06-24" @default.
- W1966184433 creator A5011753600 @default.
- W1966184433 creator A5040072237 @default.
- W1966184433 creator A5043773976 @default.
- W1966184433 date "1996-06-01" @default.
- W1966184433 modified "2023-10-18" @default.
- W1966184433 title "Moclobemide: a paradigm of research in clinical psychopharmacology" @default.
- W1966184433 doi "https://doi.org/10.1097/00004850-199606003-00002" @default.
- W1966184433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8923103" @default.
- W1966184433 hasPublicationYear "1996" @default.
- W1966184433 type Work @default.
- W1966184433 sameAs 1966184433 @default.
- W1966184433 citedByCount "4" @default.
- W1966184433 crossrefType "journal-article" @default.
- W1966184433 hasAuthorship W1966184433A5011753600 @default.
- W1966184433 hasAuthorship W1966184433A5040072237 @default.
- W1966184433 hasAuthorship W1966184433A5043773976 @default.
- W1966184433 hasConcept C118552586 @default.
- W1966184433 hasConcept C126322002 @default.
- W1966184433 hasConcept C15744967 @default.
- W1966184433 hasConcept C181199279 @default.
- W1966184433 hasConcept C185592680 @default.
- W1966184433 hasConcept C197934379 @default.
- W1966184433 hasConcept C2776024655 @default.
- W1966184433 hasConcept C2777198177 @default.
- W1966184433 hasConcept C2778375690 @default.
- W1966184433 hasConcept C2778689640 @default.
- W1966184433 hasConcept C2779177272 @default.
- W1966184433 hasConcept C2780237459 @default.
- W1966184433 hasConcept C535046627 @default.
- W1966184433 hasConcept C55493867 @default.
- W1966184433 hasConcept C558461103 @default.
- W1966184433 hasConcept C71924100 @default.
- W1966184433 hasConcept C98274493 @default.
- W1966184433 hasConceptScore W1966184433C118552586 @default.
- W1966184433 hasConceptScore W1966184433C126322002 @default.
- W1966184433 hasConceptScore W1966184433C15744967 @default.
- W1966184433 hasConceptScore W1966184433C181199279 @default.
- W1966184433 hasConceptScore W1966184433C185592680 @default.
- W1966184433 hasConceptScore W1966184433C197934379 @default.
- W1966184433 hasConceptScore W1966184433C2776024655 @default.
- W1966184433 hasConceptScore W1966184433C2777198177 @default.
- W1966184433 hasConceptScore W1966184433C2778375690 @default.
- W1966184433 hasConceptScore W1966184433C2778689640 @default.
- W1966184433 hasConceptScore W1966184433C2779177272 @default.
- W1966184433 hasConceptScore W1966184433C2780237459 @default.
- W1966184433 hasConceptScore W1966184433C535046627 @default.
- W1966184433 hasConceptScore W1966184433C55493867 @default.
- W1966184433 hasConceptScore W1966184433C558461103 @default.
- W1966184433 hasConceptScore W1966184433C71924100 @default.
- W1966184433 hasConceptScore W1966184433C98274493 @default.
- W1966184433 hasIssue "Supplement 3" @default.
- W1966184433 hasLocation W19661844331 @default.
- W1966184433 hasLocation W19661844332 @default.
- W1966184433 hasOpenAccess W1966184433 @default.
- W1966184433 hasPrimaryLocation W19661844331 @default.
- W1966184433 hasRelatedWork W1993534000 @default.
- W1966184433 hasRelatedWork W2004465552 @default.
- W1966184433 hasRelatedWork W2009084313 @default.
- W1966184433 hasRelatedWork W2033671168 @default.
- W1966184433 hasRelatedWork W2056689672 @default.
- W1966184433 hasRelatedWork W2091216391 @default.
- W1966184433 hasRelatedWork W2255694279 @default.
- W1966184433 hasRelatedWork W2400389887 @default.
- W1966184433 hasRelatedWork W2418936755 @default.
- W1966184433 hasRelatedWork W2480782045 @default.
- W1966184433 hasVolume "11" @default.
- W1966184433 isParatext "false" @default.
- W1966184433 isRetracted "false" @default.
- W1966184433 magId "1966184433" @default.
- W1966184433 workType "article" @default.