Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966185752> ?p ?o ?g. }
- W1966185752 endingPage "700" @default.
- W1966185752 startingPage "687" @default.
- W1966185752 abstract "We have re-examined whether N-methyl-d-aspartate receptors play a specific role in experience-dependent plasticity in kitten visual cortex. A specific antagonist of this glutamate receptor subtype, d,l-2-amino-5-phosphonovaleric acid, was directly and continuously infused into kitten striate cortex for one week concurrently with monocular lid suture. In the hemisphere infused with 50 mM antagonist, we found the usual shift in ocular dominance toward the open eye with only a few binocular cells remaining. The changes were accompanied by an extremely high incidence (38%) of abnormal cells lacking orientation selectivity across different ocular dominance groups. In kitten cortex infused with 10 mM antagonist concurrently with monocular deprivation for a week, recording from a drug-affected region near the infusion centre, we again found the U-shaped ocular dominance distribution with the high incidence of non-selective cells. In antagonist-infused, otherwise normal striate cortex of adult cats, we found that the proportion of binocular cells decreased by one-half in two cell populations: one recorded during the continuous infusion of 10 mM antagonist under general anaesthesia and paralysis and the other about two days after stopping the infusion. We also established that in vivo concentrations of chronically infused 10 mM antagonist decreased, not near-exponentially, but linearly with increasing distance from the infusion site. Thus, the effects of a directly and continuously infused concentrated antagonist of N-methyl-d-aspartate receptors on receptive-field properties of visuocortical cells are complex. The present findings strongly suggest that the antagonist effects in the developing cortex may be due primarily to blockade of normal synaptic transmission rather than specific disruption of an experience-dependent mechanism underlying ocular dominance plasticity." @default.
- W1966185752 created "2016-06-24" @default.
- W1966185752 creator A5013874722 @default.
- W1966185752 creator A5047491013 @default.
- W1966185752 creator A5050708035 @default.
- W1966185752 creator A5055814028 @default.
- W1966185752 creator A5058079696 @default.
- W1966185752 creator A5062350282 @default.
- W1966185752 date "1997-10-01" @default.
- W1966185752 modified "2023-09-23" @default.
- W1966185752 title "Roles of N-methyl-d-aspartate receptors in ocular dominance plasticity in developing visual cortex: re-evaluation" @default.
- W1966185752 cites W1248076745 @default.
- W1966185752 cites W148261105 @default.
- W1966185752 cites W1818037582 @default.
- W1966185752 cites W1870538900 @default.
- W1966185752 cites W1964393251 @default.
- W1966185752 cites W1980715428 @default.
- W1966185752 cites W1981520343 @default.
- W1966185752 cites W1998305119 @default.
- W1966185752 cites W1999160850 @default.
- W1966185752 cites W2004277714 @default.
- W1966185752 cites W2011999599 @default.
- W1966185752 cites W2012841327 @default.
- W1966185752 cites W2016376181 @default.
- W1966185752 cites W2017171491 @default.
- W1966185752 cites W2021283471 @default.
- W1966185752 cites W2025725930 @default.
- W1966185752 cites W2026389045 @default.
- W1966185752 cites W2028596158 @default.
- W1966185752 cites W2035841782 @default.
- W1966185752 cites W2036512556 @default.
- W1966185752 cites W2040744159 @default.
- W1966185752 cites W2047275938 @default.
- W1966185752 cites W2051069074 @default.
- W1966185752 cites W2053837059 @default.
- W1966185752 cites W2058148599 @default.
- W1966185752 cites W2077251473 @default.
- W1966185752 cites W2085872157 @default.
- W1966185752 cites W2116360511 @default.
- W1966185752 cites W2134646026 @default.
- W1966185752 cites W2166938907 @default.
- W1966185752 cites W2180941170 @default.
- W1966185752 cites W2416935468 @default.
- W1966185752 cites W2460840553 @default.
- W1966185752 cites W2472859161 @default.
- W1966185752 cites W4236811700 @default.
- W1966185752 cites W995855963 @default.
- W1966185752 cites W1972778714 @default.
- W1966185752 cites W1992365949 @default.
- W1966185752 doi "https://doi.org/10.1016/s0306-4522(97)00222-4" @default.
- W1966185752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9483528" @default.
- W1966185752 hasPublicationYear "1997" @default.
- W1966185752 type Work @default.
- W1966185752 sameAs 1966185752 @default.
- W1966185752 citedByCount "31" @default.
- W1966185752 countsByYear W19661857522012 @default.
- W1966185752 countsByYear W19661857522014 @default.
- W1966185752 countsByYear W19661857522020 @default.
- W1966185752 crossrefType "journal-article" @default.
- W1966185752 hasAuthorship W1966185752A5013874722 @default.
- W1966185752 hasAuthorship W1966185752A5047491013 @default.
- W1966185752 hasAuthorship W1966185752A5050708035 @default.
- W1966185752 hasAuthorship W1966185752A5055814028 @default.
- W1966185752 hasAuthorship W1966185752A5058079696 @default.
- W1966185752 hasAuthorship W1966185752A5062350282 @default.
- W1966185752 hasConcept C126322002 @default.
- W1966185752 hasConcept C134018914 @default.
- W1966185752 hasConcept C169760540 @default.
- W1966185752 hasConcept C170493617 @default.
- W1966185752 hasConcept C183836922 @default.
- W1966185752 hasConcept C19071747 @default.
- W1966185752 hasConcept C2776885963 @default.
- W1966185752 hasConcept C2778122271 @default.
- W1966185752 hasConcept C2778749613 @default.
- W1966185752 hasConcept C2779345533 @default.
- W1966185752 hasConcept C2779904517 @default.
- W1966185752 hasConcept C6084040 @default.
- W1966185752 hasConcept C67018056 @default.
- W1966185752 hasConcept C71924100 @default.
- W1966185752 hasConcept C86803240 @default.
- W1966185752 hasConceptScore W1966185752C126322002 @default.
- W1966185752 hasConceptScore W1966185752C134018914 @default.
- W1966185752 hasConceptScore W1966185752C169760540 @default.
- W1966185752 hasConceptScore W1966185752C170493617 @default.
- W1966185752 hasConceptScore W1966185752C183836922 @default.
- W1966185752 hasConceptScore W1966185752C19071747 @default.
- W1966185752 hasConceptScore W1966185752C2776885963 @default.
- W1966185752 hasConceptScore W1966185752C2778122271 @default.
- W1966185752 hasConceptScore W1966185752C2778749613 @default.
- W1966185752 hasConceptScore W1966185752C2779345533 @default.
- W1966185752 hasConceptScore W1966185752C2779904517 @default.
- W1966185752 hasConceptScore W1966185752C6084040 @default.
- W1966185752 hasConceptScore W1966185752C67018056 @default.
- W1966185752 hasConceptScore W1966185752C71924100 @default.
- W1966185752 hasConceptScore W1966185752C86803240 @default.
- W1966185752 hasIssue "3" @default.
- W1966185752 hasLocation W19661857521 @default.
- W1966185752 hasLocation W19661857522 @default.