FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966200061> ?p ?o ?g. }

• W1966200061 endingPage "304" @default.
• W1966200061 startingPage "288" @default.
• W1966200061 abstract "Somatostatins are a brain peptide family centered on a 14-amino acid cyclic peptide (SS-14) and a 28-amino acid N-terminally extended form (SS-28). Using radioiodinated analogs of SS-14 and SS-28, we have identified specific binding sites in rat and human brain sections that display pharmacological properties anticipated for somatostatin receptors and discrete patterns of anatomical localization. High binding densities are found in many forebrain regions, with special densities in infragranular cerebral cortical laminae in rat and human brain. In the rat, other densities lie in olfactory zones, lateral and triangular septal nuclei, the CA-1 hippocampal region, and claustrum with moderate densities in the striatum. Discrete hypothalamic areas, especially the median preoptic, paraventricular, and periventricular nuclei, display elevated binding levels, while the thalamus shows only scattered areas of modest binding. Midbrain receptor concentrations are found in portions of the periaqueductal gray, interpeduncular nucleus, and the substantia nigra. Notable pontine and medullary densities lie in the locus coeruleus, fourth ventricular floor, parabrachial, solitary, prepositus hypoglossal, dorsal column, and caudal trigeminal zones. Although the cerebellar cortex shows unimpressive densities, each of the deep cerebellar nuclei is heavily labeled. Modest spinal cord receptor densities are concentrated in the substantia gelatinosa and central cord regions. These localizations show many parallels with the distributions of SS-immunoreactive neurons, fibers, and terminals determined previously by immunohistochemistry. They provide plausible loci for several reported physiological or pharmacological activities of the SS-peptides, and may improve understanding of the role of the SS alterations described in several human neurodegenerative disorders." @default.
• W1966200061 created "2016-06-24" @default.
• W1966200061 creator A5020208893 @default.
• W1966200061 creator A5061872948 @default.
• W1966200061 creator A5072054080 @default.
• W1966200061 creator A5080194494 @default.
• W1966200061 date "1985-10-15" @default.
• W1966200061 modified "2023-10-14" @default.
• W1966200061 title "Somatostatin receptors: Distribution in rat central nervous system and human frontal cortex" @default.
• W1966200061 cites W1518696936 @default.
• W1966200061 cites W1600423268 @default.
• W1966200061 cites W1755213817 @default.
• W1966200061 cites W1966555792 @default.
• W1966200061 cites W1967176134 @default.
• W1966200061 cites W1976870395 @default.
• W1966200061 cites W1978591091 @default.
• W1966200061 cites W1982719361 @default.
• W1966200061 cites W1986829186 @default.
• W1966200061 cites W1987250152 @default.
• W1966200061 cites W1988685031 @default.
• W1966200061 cites W1989596698 @default.
• W1966200061 cites W1997195014 @default.
• W1966200061 cites W1998182926 @default.
• W1966200061 cites W2004249932 @default.
• W1966200061 cites W2004637297 @default.
• W1966200061 cites W2007567221 @default.
• W1966200061 cites W2013000582 @default.
• W1966200061 cites W2013651799 @default.
• W1966200061 cites W2013905850 @default.
• W1966200061 cites W2018299299 @default.
• W1966200061 cites W2019224452 @default.
• W1966200061 cites W2024021125 @default.
• W1966200061 cites W2029704740 @default.
• W1966200061 cites W2030546931 @default.
• W1966200061 cites W2033749317 @default.
• W1966200061 cites W2034969383 @default.
• W1966200061 cites W2039776384 @default.
• W1966200061 cites W2041876676 @default.
• W1966200061 cites W2045082171 @default.
• W1966200061 cites W2047212581 @default.
• W1966200061 cites W2054950553 @default.
• W1966200061 cites W2055877450 @default.
• W1966200061 cites W2059673451 @default.
• W1966200061 cites W2061899493 @default.
• W1966200061 cites W2064840510 @default.
• W1966200061 cites W2064859873 @default.
• W1966200061 cites W2065210810 @default.
• W1966200061 cites W2069230122 @default.
• W1966200061 cites W2071081807 @default.
• W1966200061 cites W2071310612 @default.
• W1966200061 cites W2071948811 @default.
• W1966200061 cites W2079643923 @default.
• W1966200061 cites W2079763448 @default.
• W1966200061 cites W2082281194 @default.
• W1966200061 cites W2085772416 @default.
• W1966200061 cites W2088199561 @default.
• W1966200061 cites W2092481738 @default.
• W1966200061 cites W2093070695 @default.
• W1966200061 cites W2100611368 @default.
• W1966200061 cites W2130115758 @default.
• W1966200061 cites W2150425618 @default.
• W1966200061 cites W2150561524 @default.
• W1966200061 cites W4243400726 @default.
• W1966200061 cites W4252714631 @default.
• W1966200061 cites W4301765961 @default.
• W1966200061 doi "https://doi.org/10.1002/cne.902400306" @default.
• W1966200061 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2866202" @default.
• W1966200061 hasPublicationYear "1985" @default.
• W1966200061 type Work @default.
• W1966200061 sameAs 1966200061 @default.
• W1966200061 citedByCount "132" @default.
• W1966200061 countsByYear W19662000612013 @default.
• W1966200061 countsByYear W19662000612014 @default.
• W1966200061 countsByYear W19662000612015 @default.
• W1966200061 countsByYear W19662000612018 @default.
• W1966200061 countsByYear W19662000612019 @default.
• W1966200061 countsByYear W19662000612023 @default.
• W1966200061 crossrefType "journal-article" @default.
• W1966200061 hasAuthorship W1966200061A5020208893 @default.
• W1966200061 hasAuthorship W1966200061A5061872948 @default.
• W1966200061 hasAuthorship W1966200061A5072054080 @default.
• W1966200061 hasAuthorship W1966200061A5080194494 @default.
• W1966200061 hasConcept C105702510 @default.
• W1966200061 hasConcept C137183658 @default.
• W1966200061 hasConcept C169760540 @default.
• W1966200061 hasConcept C24998067 @default.
• W1966200061 hasConcept C2779715522 @default.
• W1966200061 hasConcept C2780938664 @default.
• W1966200061 hasConcept C2781069035 @default.
• W1966200061 hasConcept C2781304537 @default.
• W1966200061 hasConcept C2781404750 @default.
• W1966200061 hasConcept C2909432713 @default.
• W1966200061 hasConcept C44107871 @default.
• W1966200061 hasConcept C513476851 @default.
• W1966200061 hasConcept C529278444 @default.
• W1966200061 hasConcept C552161191 @default.
• W1966200061 hasConcept C86803240 @default.
• W1966200061 hasConceptScore W1966200061C105702510 @default.

• next