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• W1966200069 abstract "Abnormalities in several hypothalamic-pituitary-target organ axes in depression may reflect alterations in central neurotransmitter receptor function. As the α2-adrenergic receptor has been implicated in a variety of neuroendocrine abnormalities in depression, we assessed the role of α2-adrenoceptor dysfunction in mediating response abnormalities of growth hormone, cortisol, and prolactin after intravenous clonidine administration (an α2-adrenergic receptor agonist) in 18 patients with major depression (12 with melancholic features, 6 without melancholic symptoms) and 9 healthy volunteers. In particular, we examined the hypothesis that these abnormalities might be more evident in patients with DSM-III melancholic depression. After clonidine, the mean growth hormone response was significantly lower in melancholic depressives compared to controls (p = 0.02), and the shape of the growth hormone response profile was also significantly different in melancholic patients (p = 0.04). There was an overall decrease in the mean cortisol concentration after clonidine in melancholic patients and control subjects (p = 0.02), as well as a larger cumulative prolactin response in melancholic patients compared to those without melancholic features (p = 0.02). The present results confirm prior observations of a blunted growth hormone response after clonidine and suggest that alterations in α2-adrenergic receptor activity might also contribute to several neuroen-docrine abnormalities in patients with melancholic depression." @default.
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• W1966200069 date "1989-07-01" @default.
• W1966200069 modified "2023-09-23" @default.
• W1966200069 title "Multiple hormone responses to clonidine administration in depressed patients and healthy volunteers" @default.
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• W1966200069 doi "https://doi.org/10.1016/0006-3223(89)90039-5" @default.
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