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- W1966201140 abstract "The first case of Whipple's disease (intestinal lipodystrophy) in which were found both a marked elevation of the serum glycoprotein and deposits of glycoprotein in the characteristic macrophages is reported. This association may represent a fundamental pathogenetic relationship. We also wish to emphasize certain diagnostic and therapeutic features of Whipple's disease. Whipple 1 in 1907 described a disease characterized clinically by vague abdominal distress, steatorrhea, progressive loss of weight and strength, and arthralgia. His patient was a 36-year-old physician, who died following abdominal exploration. The clinical diagnosis had been tuberculous mesenteric lymphadenitis. Histologically the lamina propria of the small intestine and the mesenteric lymph nodes showed a striking accumulation of mononuclear cells and deposits of fat and fatty acids. The foamy macrophages were found predominantly in the lamina propria and to a lesser degree in the lymph nodes, where the lesion was basically a lipogranuloma. Whipple noted that" @default.
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- W1966201140 date "1953-05-23" @default.
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- W1966201140 title "WHIPPLE'S DISEASE (INTESTINAL LIPODYSTROPHY) AND SERUM GLYCOPROTEINS" @default.
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- W1966201140 doi "https://doi.org/10.1001/jama.1953.03690040016006" @default.
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