FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966205227> ?p ?o ?g. }

• W1966205227 endingPage "60" @default.
• W1966205227 startingPage "54" @default.
• W1966205227 abstract "The traditional human kallikrein gene family consists of three genes, namely KLK1 [encoding human kallikrein 1 (hK1) or pancreatic/renal kallikrein], KLK2 (encoding hK2, previously known as human glandular kallikrein 1) and KLK3 [encoding hK3 or prostate-specific antigen (PSA)]. KLK2 and KLK3 have important applications in prostate cancer diagnostics and, more recently, in breast cancer diagnostics. During the past two to three years, new putative members of the human kallikrein gene family have been identified, including the PRSSL1 gene [encoding normal epithelial cell-specific 1 gene (NES1)], the gene encoding zyme/protease M/neurosin, the gene encoding prostase/KLK-L1, and the genes encoding neuropsin, stratum corneum chymotryptic enzyme and trypsin-like serine protease. Another five putative kallikrein genes, provisionally named KLK-L2, KLK-L3, KLK-L4, KLK-L5 and KLK-L6, have also been identified. Many of the newly identified kallikrein-like genes are regulated by steroid hormones, and a few kallikreins (NES1, protease M, PSA) are known to be downregulated in breast and possibly other cancers. NES1 appears to be a novel breast cancer tumor suppressor protein and PSA a potent inhibitor of angiogenesis. This brief review summarizes recent developments and possible applications of the newly defined and expanded human kallikrein gene locus." @default.
• W1966205227 created "2016-06-24" @default.
• W1966205227 creator A5028560597 @default.
• W1966205227 creator A5038476466 @default.
• W1966205227 creator A5051176318 @default.
• W1966205227 creator A5056325273 @default.
• W1966205227 creator A5084226800 @default.
• W1966205227 date "2000-03-01" @default.
• W1966205227 modified "2023-10-10" @default.
• W1966205227 title "The New Human Kallikrein Gene Family: Implications in Carcinogenesis" @default.
• W1966205227 cites W1484454235 @default.
• W1966205227 cites W1568172136 @default.
• W1966205227 cites W1585578035 @default.
• W1966205227 cites W1757871111 @default.
• W1966205227 cites W1855549123 @default.
• W1966205227 cites W1946201399 @default.
• W1966205227 cites W1966110638 @default.
• W1966205227 cites W1966503229 @default.
• W1966205227 cites W1978858571 @default.
• W1966205227 cites W1985043450 @default.
• W1966205227 cites W2003569879 @default.
• W1966205227 cites W2015278187 @default.
• W1966205227 cites W2017827421 @default.
• W1966205227 cites W2019609101 @default.
• W1966205227 cites W2020785470 @default.
• W1966205227 cites W2025198871 @default.
• W1966205227 cites W2031314819 @default.
• W1966205227 cites W2066560328 @default.
• W1966205227 cites W2076686856 @default.
• W1966205227 cites W2111066303 @default.
• W1966205227 cites W2114286587 @default.
• W1966205227 cites W2121199363 @default.
• W1966205227 cites W2134235648 @default.
• W1966205227 cites W2140773726 @default.
• W1966205227 cites W2140798291 @default.
• W1966205227 cites W2153964837 @default.
• W1966205227 cites W2163865726 @default.
• W1966205227 cites W2168181029 @default.
• W1966205227 cites W4205307388 @default.
• W1966205227 cites W4244418526 @default.
• W1966205227 cites W4253061118 @default.
• W1966205227 doi "https://doi.org/10.1016/s1043-2760(99)00225-8" @default.
• W1966205227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10675891" @default.
• W1966205227 hasPublicationYear "2000" @default.
• W1966205227 type Work @default.
• W1966205227 sameAs 1966205227 @default.
• W1966205227 citedByCount "262" @default.
• W1966205227 countsByYear W19662052272012 @default.
• W1966205227 countsByYear W19662052272013 @default.
• W1966205227 countsByYear W19662052272014 @default.
• W1966205227 countsByYear W19662052272015 @default.
• W1966205227 countsByYear W19662052272016 @default.
• W1966205227 countsByYear W19662052272017 @default.
• W1966205227 countsByYear W19662052272018 @default.
• W1966205227 countsByYear W19662052272019 @default.
• W1966205227 countsByYear W19662052272020 @default.
• W1966205227 countsByYear W19662052272022 @default.
• W1966205227 countsByYear W19662052272023 @default.
• W1966205227 crossrefType "journal-article" @default.
• W1966205227 hasAuthorship W1966205227A5028560597 @default.
• W1966205227 hasAuthorship W1966205227A5038476466 @default.
• W1966205227 hasAuthorship W1966205227A5051176318 @default.
• W1966205227 hasAuthorship W1966205227A5056325273 @default.
• W1966205227 hasAuthorship W1966205227A5084226800 @default.
• W1966205227 hasConcept C104317684 @default.
• W1966205227 hasConcept C121608353 @default.
• W1966205227 hasConcept C150194340 @default.
• W1966205227 hasConcept C181199279 @default.
• W1966205227 hasConcept C2780192828 @default.
• W1966205227 hasConcept C502942594 @default.
• W1966205227 hasConcept C52853521 @default.
• W1966205227 hasConcept C54355233 @default.
• W1966205227 hasConcept C55493867 @default.
• W1966205227 hasConcept C5911399 @default.
• W1966205227 hasConcept C86803240 @default.
• W1966205227 hasConceptScore W1966205227C104317684 @default.
• W1966205227 hasConceptScore W1966205227C121608353 @default.
• W1966205227 hasConceptScore W1966205227C150194340 @default.
• W1966205227 hasConceptScore W1966205227C181199279 @default.
• W1966205227 hasConceptScore W1966205227C2780192828 @default.
• W1966205227 hasConceptScore W1966205227C502942594 @default.
• W1966205227 hasConceptScore W1966205227C52853521 @default.
• W1966205227 hasConceptScore W1966205227C54355233 @default.
• W1966205227 hasConceptScore W1966205227C55493867 @default.
• W1966205227 hasConceptScore W1966205227C5911399 @default.
• W1966205227 hasConceptScore W1966205227C86803240 @default.
• W1966205227 hasIssue "2" @default.
• W1966205227 hasLocation W19662052271 @default.
• W1966205227 hasLocation W19662052272 @default.
• W1966205227 hasOpenAccess W1966205227 @default.
• W1966205227 hasPrimaryLocation W19662052271 @default.
• W1966205227 hasRelatedWork W1562691154 @default.
• W1966205227 hasRelatedWork W2019984181 @default.
• W1966205227 hasRelatedWork W2343041331 @default.
• W1966205227 hasRelatedWork W2377242758 @default.
• W1966205227 hasRelatedWork W2907705195 @default.
• W1966205227 hasRelatedWork W2989871178 @default.
• W1966205227 hasRelatedWork W2999653847 @default.

• next