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- W1966205912 abstract "To examine whether there are any correlation between the degree of sperm DNA fragmentation as measured with Sperm Chromatin Structure assay (SCSA) and early embryo development assessed by time-lapse microscopy. The study was performed in a retrospective manner in the setting of a university hospital clinic. The study included 642 oocytes from 107 couples treated with Intracytoplasmatic Sperm Injection (ICSI). Embryos were cultured in a Embryoscope (time-lapse system), with 6% CO2 and 5% O2 for a maximum of six days. All annotations for each zygote/embryo were performed in regard to predefined morphokinetic events. The semen sample was collected at the day of oocyte aspiration and the degree of DNA fragmentation was assessed using the SCSA. The percentage of denatured, damaged DNA was expressed as DFI (DNA Fragmentation Index). Oocytes/embryos were categorized into four different groups according to DFI value (0-10%; 10.1-20%; 20.1-30% and >30%). The endpoints were fertilization rate as well as time for: i) extrusion of second polarbody (2PBe); ii) pronuclei appearance (PNa); iii) pronuclei fading (PNf); iv) early cleavage (t2); v) blastocyst development (tB) and vi) blastocyst rate. Mean values for all parameters were tested in a linear regression analysis model with the respective parameters as dependant and the four DFI categories as independent factors. Statistical analysis was performed using statistical software (SPSS 17.0 for Windows; SPSS Inc., Chicago,IL). A p-value of less than 0.05 was considered statistically significant. For all endpoints; rate of 2PN, 2PBe, PNa, PNf, t2, tB and blastocyst rate the mean numbers were equal between all four DFI groups. No statistical differences between groups were detected. Neither rate of 2PN, 2PBe, PNa, PNf nor embryo development as assessed by time-lapse microscopy are related to degree of sperm DNA fragmentation as measured by SCSA." @default.
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- W1966205912 date "2014-09-01" @default.
- W1966205912 modified "2023-09-26" @default.
- W1966205912 title "Evaluation of sperm DNA integrity and its effect on embryo development using time-lapse microscopy" @default.
- W1966205912 doi "https://doi.org/10.1016/j.fertnstert.2014.07.1059" @default.
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