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• W1966206265 abstract "Staphylococcal enterotoxin B (SEB) causes lethal shock by potently stimulating the host immune response. Dexamethasone and N-acetyl cysteine (NAC) are anti-inflammatory and antioxidative drugs, respectively, which can independently modulate immune function. Dexamethasone was previously shown to be effective in preventing SEB-induced shock models only if administered early and in multiple doses for a long duration. In this study, dexamethasone and NAC were used in tandem and protected mice (75%) against SEB-induced lethal shock. Hypothermia and weight loss elicited by SEB were also diminished by this novel combination treatment. The levels of monocyte chemoattractant protein-1, interleukin-2, interleukin-6, and mouse gamma interferon in lung tissue after intranasal exposure to SEB were also significantly reduced in mice given a combination of dexamethasone and NAC versus controls." @default.
• W1966206265 created "2016-06-24" @default.
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• W1966206265 date "2013-09-01" @default.
• W1966206265 modified "2023-09-23" @default.
• W1966206265 title "Efficacy of Two FDA-Approved Drug Combination in a Mouse Model of Staphylococcal Enterotoxin B-Induced Shock" @default.
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• W1966206265 doi "https://doi.org/10.7205/milmed-d-13-00129" @default.
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