Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966209014> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1966209014 endingPage "21" @default.
- W1966209014 startingPage "19" @default.
- W1966209014 abstract "The chromatin environment dictates activity throughout the genome. Post-translational modification of the N-terminal tails of histone proteins allow nucleosomes to shift, the chromatin to relax and genes to become activated. Histone modification events and markers will change in response to environmental stimuli; therefore they present a method for identification of sites of transcription factor activity. 1,25-Dihydroxyvitamin D3 induces the vitamin D receptor (VDR) to bind to DNA and activate transcription. These actions alter the chromatin environment and can be detected by increases or decreases in the histone modifications. In fact, in genomic loci with multiple enhancers, selective modulation of those enhancers after vitamin D3 stimulation can be readily detected by histone modifications. We provide an example of these actions on the Mmp13 gene locus where VDR binds selectively to an enhancer 10kb upstream of the transcriptional start site. This binding event is accompanied by an enhancer-selective increase in histone 3 lysine 9 acetylation (H3K9Ac). ChIP-seq analysis of histone modifications requires less genomic material than transcription factor ChIP-seq, thus proving advantageous to in vivo assays with limited cellular material. Therefore, histone modification activity alone may be used as a guide for discovering sites of VDR action for further biochemical analysis. This article is part of a Special Issue entitled '16th Vitamin D Workshop'." @default.
- W1966209014 created "2016-06-24" @default.
- W1966209014 creator A5023230304 @default.
- W1966209014 creator A5049270000 @default.
- W1966209014 creator A5059271008 @default.
- W1966209014 date "2014-10-01" @default.
- W1966209014 modified "2023-09-25" @default.
- W1966209014 title "1,25-Dihydroxyvitamin D3 induced histone profiles guide discovery of VDR action sites" @default.
- W1966209014 cites W1968869424 @default.
- W1966209014 cites W1978661875 @default.
- W1966209014 cites W1988290071 @default.
- W1966209014 cites W1993967111 @default.
- W1966209014 cites W2001523917 @default.
- W1966209014 cites W2014677321 @default.
- W1966209014 cites W2036158314 @default.
- W1966209014 cites W2043224349 @default.
- W1966209014 cites W2049869291 @default.
- W1966209014 cites W2083245183 @default.
- W1966209014 cites W2093915139 @default.
- W1966209014 cites W2142522655 @default.
- W1966209014 cites W2153919418 @default.
- W1966209014 doi "https://doi.org/10.1016/j.jsbmb.2013.09.005" @default.
- W1966209014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3954960" @default.
- W1966209014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24041718" @default.
- W1966209014 hasPublicationYear "2014" @default.
- W1966209014 type Work @default.
- W1966209014 sameAs 1966209014 @default.
- W1966209014 citedByCount "22" @default.
- W1966209014 countsByYear W19662090142014 @default.
- W1966209014 countsByYear W19662090142015 @default.
- W1966209014 countsByYear W19662090142016 @default.
- W1966209014 countsByYear W19662090142018 @default.
- W1966209014 countsByYear W19662090142019 @default.
- W1966209014 countsByYear W19662090142020 @default.
- W1966209014 countsByYear W19662090142021 @default.
- W1966209014 countsByYear W19662090142022 @default.
- W1966209014 countsByYear W19662090142023 @default.
- W1966209014 crossrefType "journal-article" @default.
- W1966209014 hasAuthorship W1966209014A5023230304 @default.
- W1966209014 hasAuthorship W1966209014A5049270000 @default.
- W1966209014 hasAuthorship W1966209014A5059271008 @default.
- W1966209014 hasBestOaLocation W19662090142 @default.
- W1966209014 hasConcept C10058791 @default.
- W1966209014 hasConcept C101762097 @default.
- W1966209014 hasConcept C104317684 @default.
- W1966209014 hasConcept C111936080 @default.
- W1966209014 hasConcept C121912465 @default.
- W1966209014 hasConcept C134320426 @default.
- W1966209014 hasConcept C150194340 @default.
- W1966209014 hasConcept C179639408 @default.
- W1966209014 hasConcept C190727270 @default.
- W1966209014 hasConcept C54355233 @default.
- W1966209014 hasConcept C64927066 @default.
- W1966209014 hasConcept C83640560 @default.
- W1966209014 hasConcept C84772758 @default.
- W1966209014 hasConcept C86339819 @default.
- W1966209014 hasConcept C86803240 @default.
- W1966209014 hasConcept C95444343 @default.
- W1966209014 hasConceptScore W1966209014C10058791 @default.
- W1966209014 hasConceptScore W1966209014C101762097 @default.
- W1966209014 hasConceptScore W1966209014C104317684 @default.
- W1966209014 hasConceptScore W1966209014C111936080 @default.
- W1966209014 hasConceptScore W1966209014C121912465 @default.
- W1966209014 hasConceptScore W1966209014C134320426 @default.
- W1966209014 hasConceptScore W1966209014C150194340 @default.
- W1966209014 hasConceptScore W1966209014C179639408 @default.
- W1966209014 hasConceptScore W1966209014C190727270 @default.
- W1966209014 hasConceptScore W1966209014C54355233 @default.
- W1966209014 hasConceptScore W1966209014C64927066 @default.
- W1966209014 hasConceptScore W1966209014C83640560 @default.
- W1966209014 hasConceptScore W1966209014C84772758 @default.
- W1966209014 hasConceptScore W1966209014C86339819 @default.
- W1966209014 hasConceptScore W1966209014C86803240 @default.
- W1966209014 hasConceptScore W1966209014C95444343 @default.
- W1966209014 hasLocation W19662090141 @default.
- W1966209014 hasLocation W19662090142 @default.
- W1966209014 hasLocation W19662090143 @default.
- W1966209014 hasLocation W19662090144 @default.
- W1966209014 hasOpenAccess W1966209014 @default.
- W1966209014 hasPrimaryLocation W19662090141 @default.
- W1966209014 hasRelatedWork W1966209014 @default.
- W1966209014 hasRelatedWork W1986865417 @default.
- W1966209014 hasRelatedWork W2038849570 @default.
- W1966209014 hasRelatedWork W2106150437 @default.
- W1966209014 hasRelatedWork W2156241244 @default.
- W1966209014 hasRelatedWork W2166037178 @default.
- W1966209014 hasRelatedWork W2415548889 @default.
- W1966209014 hasRelatedWork W2500498803 @default.
- W1966209014 hasRelatedWork W2790817862 @default.
- W1966209014 hasRelatedWork W3028625379 @default.
- W1966209014 hasVolume "144" @default.
- W1966209014 isParatext "false" @default.
- W1966209014 isRetracted "false" @default.
- W1966209014 magId "1966209014" @default.
- W1966209014 workType "article" @default.