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- W1966209203 abstract "Because tuberculosis among the foreign-born is of increasing importance in North America, it has recently been recommended that newly arriving immigrants be tuberculin tested and preventive therapy given to all those with significant reactions. The factors affecting the prevalence of tuberculin reactions were assessed in a community-based tuberculin survey among foreign-born schoolchildren and young adults. Of 1,198 foreign-born who were tuberculin tested, 32.4% had significant tuberculin reactions. False-positive tuberculin reactions due to sensitivity to purified protein derivative (PPD)-B (for Mycobacterium avium) were uncommon and those due to BCG vaccination of importance only among immigrants from countries with low tuberculosis rates. Tuberculin reactions of 10+ mm were associated with tuberculosis rates in the country of origin (p ⩽ 0.001), age when immigrated (p ⩽ 0.001), bacillus Calmette-Guérin (BCG) vaccination (p ⩽ 0.01), and residence in poorer neighborhoods in Montreal (p ⩽ 0.001), but not with number of years resident in Canada. The booster phenomenon, seen in 16% of those undergoing two-step testing, was most strongly associated with prior BCG vaccination (p ⩽ 0.001) and also with tuberculosis rates in the country of origin (p ⩽ 0.08), age of immigration (p ⩽ 0.01), and number of years resident in Canada (p ⩽ 0.05). Tuberculin reactions of 10+ mm should be considered to represent tuberculous infection, unless the subject immigrated at a very young age or from a country with a low tuberculosis rate. On the other hand, among all foreign-born, a significant booster effect is more likely to be due to BCG vaccination than tuberculous infection." @default.
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- W1966209203 date "1992-09-01" @default.
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- W1966209203 title "Factors Associated with Tuberculin Reactivity among the Foreign-born in Montreal" @default.
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- W1966209203 doi "https://doi.org/10.1164/ajrccm/146.3.752" @default.
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