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- W1966211045 abstract "The possibility that the presence of malignant disease can influence the metabolic activation of two carcinogens, 2-acetylaminofluorene and aflatoxin B 1 , has been investigated in a group of patients with secondary carcinoma of the liver. Mutagenic activation by subcellular fractions from biopsy samples from the patients was determined in the Ames/Salmonella test and the results compared with those obtained from a group of control patients. No significant differences were observed between the groups of patients in their ability to activate the two compounds to mutagenic metabolites. A tenfold range in ability to activate aflatoxin B 1 was observed whereas only a threefold range was obtained with 2-acetylaminofluorene. Human liver activates aflatoxin B1 approximately 100 times more efficiently than 2-acetylaminofluorene, a proven carcinogen in many species. This raises the question of the true risk to man from hepatocarcinogenicity from aflatoxin B 1 ." @default.
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- W1966211045 date "1986-01-01" @default.
- W1966211045 modified "2023-10-18" @default.
- W1966211045 title "Interindividual Differences in the Activation of Two Hepatic Carcinogens to Mutagens by Human Liver" @default.
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- W1966211045 doi "https://doi.org/10.1177/096032718600500105" @default.
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