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• W1966219770 endingPage "e97051" @default.
• W1966219770 startingPage "e97051" @default.
• W1966219770 abstract "Diseases such as type 2 diabetes, Alzheimer's and Parkinson's share as common feature the accumulation of mis-folded disease-specific protein aggregates into fibrillar structures, or plaques. These fibrils may either be toxic by themselves, or act as reservoirs for smaller cytotoxic oligomers. This suggests to investigate molecules as potential therapeutics that either reduce fibril formation or increase fibril stability. One example is rat amylin, which can inhibit aggregation of human amylin, a hallmark of type 2 diabetes. In the present paper, we use molecular dynamics to compare the stability of various preformed aggregates, built out of either human amylin, rat amylin, or mixtures of both. We considered two types of fibril-like oligomers: a single-layer in-register conformation, and a double-layer conformation in which the first U-shaped layer consists of rat amylin and the second layer of human amylin. Our results explain the weak amyloid-inhibiting properties of rat amylin and suggest that membrane leakage due to pore formation is responsible for the toxicity of rat amylin observed in a recent experiment. Together, our results put in question the use of rat amylin or the similar FDA approved drug pramlintide as an inhibitor of human amylin aggregation. They also point to mixed human-rat amylin fibril-like oligomers as possible model-systems for studies of amyloid formation that involve cross-species transmission." @default.
• W1966219770 created "2016-06-24" @default.
• W1966219770 creator A5005661488 @default.
• W1966219770 creator A5009886617 @default.
• W1966219770 date "2014-05-08" @default.
• W1966219770 modified "2023-09-27" @default.
• W1966219770 title "Inter-Species Cross-Seeding: Stability and Assembly of Rat - Human Amylin Aggregates" @default.
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• W1966219770 cites W1964727310 @default.
• W1966219770 cites W1965223596 @default.
• W1966219770 cites W1975580333 @default.
• W1966219770 cites W1980138515 @default.
• W1966219770 cites W1981793913 @default.
• W1966219770 cites W1990405999 @default.
• W1966219770 cites W1990468756 @default.
• W1966219770 cites W1991138600 @default.
• W1966219770 cites W1993121159 @default.
• W1966219770 cites W1999909300 @default.
• W1966219770 cites W2000483769 @default.
• W1966219770 cites W2000520863 @default.
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• W1966219770 cites W2009624913 @default.
• W1966219770 cites W2009856381 @default.
• W1966219770 cites W2015640782 @default.
• W1966219770 cites W2016754171 @default.
• W1966219770 cites W2021388785 @default.
• W1966219770 cites W2026306293 @default.
• W1966219770 cites W2028510176 @default.
• W1966219770 cites W2028540603 @default.
• W1966219770 cites W2028872675 @default.
• W1966219770 cites W2029514908 @default.
• W1966219770 cites W2030072508 @default.
• W1966219770 cites W2035687084 @default.
• W1966219770 cites W2038438971 @default.
• W1966219770 cites W2040931022 @default.
• W1966219770 cites W2043000650 @default.
• W1966219770 cites W2043274894 @default.
• W1966219770 cites W2046276677 @default.
• W1966219770 cites W2050891813 @default.
• W1966219770 cites W2054868321 @default.
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• W1966219770 cites W2057477511 @default.
• W1966219770 cites W2058815681 @default.
• W1966219770 cites W2059013803 @default.
• W1966219770 cites W2061685908 @default.
• W1966219770 cites W2067174909 @default.
• W1966219770 cites W2068324026 @default.
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• W1966219770 cites W2081693079 @default.
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• W1966219770 doi "https://doi.org/10.1371/journal.pone.0097051" @default.
• W1966219770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4014569" @default.
• W1966219770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24810618" @default.
• W1966219770 hasPublicationYear "2014" @default.
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