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- W1966221566 abstract "sary, for a number of practical reasons, only to assay the effect of the radiation as a quantitative, reproducible biological change; there is no pressing need to under-stand the (physiologic) mechanism from this point of view. On the other hand, there has long existed the hope-as yet largely unrealized-that radiation as such can provide a useful probe for the study and understanding of biologic mechanism. For each of these purposes there will be a utility attached to a quantitative mathematical model which can correlate at least the gross features of the resultant effect with the gross features of the normal biologic pattern. The purpose of this article is to present such a model for the interpretation of certain experiments in radiobiology. In particular, these experiments include the kind in which an animal is given a whole-body exposure to radiation, and the effect of the radiation is measured in terms of specific organ weight loss at some rather arbitrarily chosen time after the exposure. The present author's thinking in these terms first began in connection with the problem of determining the radiological effectiveness of the high-energy proton beam at the University of Chicago synchrocyclotron; in that problem, mice were exposed, and the thymus and spleen weights 5 days postexposure were used as indicators. Therefore, in what follows, there will be occasional reference to these organs for specific examples; however, the model is, within its limitations, more general. It is also true that these organs have functions which are not yet clearly understood; however, since their apparent sensitivity to radiation has made them attractive for radiobiological studies, they have also been selected for emphasis in this article. Section II will present a short discussion of the gross growth pattern of an organ like the thymus; knowledge of the growth pattern (considering only organ weight versus age) then yields the requirement for the differential equation that governs" @default.
- W1966221566 created "2016-06-24" @default.
- W1966221566 creator A5075734649 @default.
- W1966221566 date "1956-12-01" @default.
- W1966221566 modified "2023-09-24" @default.
- W1966221566 title "An Interpretation of Organ Weight Change Induced by Total-Body Irradiation" @default.
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- W1966221566 doi "https://doi.org/10.2307/3570583" @default.
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