FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966224710> ?p ?o ?g. }

• W1966224710 endingPage "217" @default.
• W1966224710 startingPage "211" @default.
• W1966224710 abstract "In vivo passage of non-pathogenic, CCR5-tropic simian/human immunodeficiency virus (SHIV) - SHIVsf162 resulted in a pathogenic isolate, SHIVsf162p3. In an attempt to characterize envelope (Env)-mediated properties that may contribute to its pathogenicity, major (P3 major) and minor (P3 minor) Env gp120 variants were cloned from the plasma of a SHIVsf162p3-infected animal, and expressed in the context of luciferase reporter viruses. Entry mediated by these envelopes and susceptibility to neutralization by CD4 induced-site (CD4i) antibodies (MAbs) was analyzed in comparison to parental SF162. Sequence analysis revealed that the P3 major and minor variant Envs contained 14 and 17 amino acid changes, respectively, compared with SF162. The rank order of entry mediated by the three envelopes was P3 major > SF162 > P3 minor, whereas the reverse order was observed for susceptibility to neutralization by CD4i MAbs. Since CD4i epitopes overlap the coreceptor (CoR) binding site, these findings suggest that the amino acid changes accumulated upon in vivo passage of SHIVsf162 result in Env gp120 structural rearrangements that modulate the exposure and/or conformation of the CoR binding site. This, in turn, led to increased entry and infectivity of the P3 major variant and may be responsible, in part, for the enhanced pathogenicity of SHIVsf162p3." @default.
• W1966224710 created "2016-06-24" @default.
• W1966224710 creator A5038068474 @default.
• W1966224710 creator A5041709499 @default.
• W1966224710 creator A5048701704 @default.
• W1966224710 creator A5054518780 @default.
• W1966224710 creator A5056076181 @default.
• W1966224710 creator A5067275151 @default.
• W1966224710 creator A5069746961 @default.
• W1966224710 date "2003-08-01" @default.
• W1966224710 modified "2023-09-23" @default.
• W1966224710 title "Antigenic variations in the CD4 induced sites of the CCR5‐tropic, pathogenic SHIV<scp>sf162p3</scp> gp120 variants" @default.
• W1966224710 cites W150399887 @default.
• W1966224710 cites W1582855350 @default.
• W1966224710 cites W1598451890 @default.
• W1966224710 cites W1628484047 @default.
• W1966224710 cites W1773346304 @default.
• W1966224710 cites W1829913979 @default.
• W1966224710 cites W1837018648 @default.
• W1966224710 cites W1915969436 @default.
• W1966224710 cites W1974138678 @default.
• W1966224710 cites W1993650351 @default.
• W1966224710 cites W2010521915 @default.
• W1966224710 cites W2019963962 @default.
• W1966224710 cites W2027738518 @default.
• W1966224710 cites W2048493260 @default.
• W1966224710 cites W2069407559 @default.
• W1966224710 cites W2072901265 @default.
• W1966224710 cites W2083803997 @default.
• W1966224710 cites W2098781795 @default.
• W1966224710 cites W2099381548 @default.
• W1966224710 cites W2100953974 @default.
• W1966224710 cites W2108256128 @default.
• W1966224710 cites W2108982073 @default.
• W1966224710 cites W2110714233 @default.
• W1966224710 cites W2111105264 @default.
• W1966224710 cites W2131903471 @default.
• W1966224710 cites W2136000813 @default.
• W1966224710 cites W2150166524 @default.
• W1966224710 cites W2164706950 @default.
• W1966224710 cites W2329251934 @default.
• W1966224710 doi "https://doi.org/10.1034/j.1600-0684.2003.00027.x" @default.
• W1966224710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14498981" @default.
• W1966224710 hasPublicationYear "2003" @default.
• W1966224710 type Work @default.
• W1966224710 sameAs 1966224710 @default.
• W1966224710 citedByCount "14" @default.
• W1966224710 countsByYear W19662247102012 @default.
• W1966224710 countsByYear W19662247102013 @default.
• W1966224710 countsByYear W19662247102015 @default.
• W1966224710 crossrefType "journal-article" @default.
• W1966224710 hasAuthorship W1966224710A5038068474 @default.
• W1966224710 hasAuthorship W1966224710A5041709499 @default.
• W1966224710 hasAuthorship W1966224710A5048701704 @default.
• W1966224710 hasAuthorship W1966224710A5054518780 @default.
• W1966224710 hasAuthorship W1966224710A5056076181 @default.
• W1966224710 hasAuthorship W1966224710A5067275151 @default.
• W1966224710 hasAuthorship W1966224710A5069746961 @default.
• W1966224710 hasConcept C104317684 @default.
• W1966224710 hasConcept C106358424 @default.
• W1966224710 hasConcept C14086860 @default.
• W1966224710 hasConcept C141231307 @default.
• W1966224710 hasConcept C151730666 @default.
• W1966224710 hasConcept C159047783 @default.
• W1966224710 hasConcept C159654299 @default.
• W1966224710 hasConcept C195616568 @default.
• W1966224710 hasConcept C2522874641 @default.
• W1966224710 hasConcept C25365240 @default.
• W1966224710 hasConcept C2779343474 @default.
• W1966224710 hasConcept C515207424 @default.
• W1966224710 hasConcept C54355233 @default.
• W1966224710 hasConcept C86803240 @default.
• W1966224710 hasConceptScore W1966224710C104317684 @default.
• W1966224710 hasConceptScore W1966224710C106358424 @default.
• W1966224710 hasConceptScore W1966224710C14086860 @default.
• W1966224710 hasConceptScore W1966224710C141231307 @default.
• W1966224710 hasConceptScore W1966224710C151730666 @default.
• W1966224710 hasConceptScore W1966224710C159047783 @default.
• W1966224710 hasConceptScore W1966224710C159654299 @default.
• W1966224710 hasConceptScore W1966224710C195616568 @default.
• W1966224710 hasConceptScore W1966224710C2522874641 @default.
• W1966224710 hasConceptScore W1966224710C25365240 @default.
• W1966224710 hasConceptScore W1966224710C2779343474 @default.
• W1966224710 hasConceptScore W1966224710C515207424 @default.
• W1966224710 hasConceptScore W1966224710C54355233 @default.
• W1966224710 hasConceptScore W1966224710C86803240 @default.
• W1966224710 hasIssue "4-5" @default.
• W1966224710 hasLocation W19662247101 @default.
• W1966224710 hasLocation W19662247102 @default.
• W1966224710 hasOpenAccess W1966224710 @default.
• W1966224710 hasPrimaryLocation W19662247101 @default.
• W1966224710 hasRelatedWork W1567514421 @default.
• W1966224710 hasRelatedWork W2037922132 @default.
• W1966224710 hasRelatedWork W2053245798 @default.
• W1966224710 hasRelatedWork W2058074887 @default.
• W1966224710 hasRelatedWork W2087994121 @default.
• W1966224710 hasRelatedWork W2088644387 @default.
• W1966224710 hasRelatedWork W2127776899 @default.

• next