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- W1966227216 abstract "Intracellular recordings from identifiable neurones in the leech segmental ganglion in high (20 mM) magnesium Ringer solution showed that (S)-3-allyl-2-methyl-4-oxocyclopent-2-enyl (1 R)-trans-chrysanthemate, (S)-bioallethrin, induced three phases of activity: (1) hyperexcitability; (2) repeated depolarisations accompanied by trains of action potentials; and (3) block of action potentials. A linear relation between log (time to onset) of both depolarisations and block and the log (applied dose) was observed over the range 3.44 × 10−7–1.10 × 10−3M. (S)-Bioallethrin was toxic to leeches at similar concentrations to those effective on isolated ganglia. The possible role of repeated depolarisations in the poisoning process is discussed." @default.
- W1966227216 created "2016-06-24" @default.
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- W1966227216 date "1977-12-01" @default.
- W1966227216 modified "2023-09-26" @default.
- W1966227216 title "The action of (S)-3-allyl-2-methyl-4-oxocyclopent-2-enyl (1 R)-trans-chrysanthemate, (S)-bioallethrin, on single neurones in the central nervous system of the leech,Hirudo medicinalis" @default.
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- W1966227216 doi "https://doi.org/10.1002/ps.2780080615" @default.
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