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- W1966227539 endingPage "176" @default.
- W1966227539 startingPage "147" @default.
- W1966227539 abstract "Antibodies, also known as immunoglobulins, have emerged as one of the most promising classes of therapeutics in the biopharmaceutical industry. The need for complete characterization of the quality attributes of these molecules requires sophisticated techniques. Mass spectrometry (MS) has become an essential analytical tool for the structural characterization of therapeutic antibodies, due to its superior resolution over other analytical techniques. It has been widely used in virtually all phases of antibody development. Structural features determined by MS include amino acid sequence, disulfide linkages, carbohydrate structure and profile, and many different post-translational, in-process, and in-storage modifications. In this review, we will discuss various MS-based techniques for the structural characterization of monoclonal antibodies. These techniques are categorized as mass determination of intact antibodies, and as middle-up, bottom-up, top-down, and middle-down structural characterizations. Each of these techniques has its advantages and disadvantages in terms of structural resolution, sequence coverage, sample consumption, and effort required for analyses. The role of MS in glycan structural characterization and profiling will also be discussed." @default.
- W1966227539 created "2016-06-24" @default.
- W1966227539 creator A5025498462 @default.
- W1966227539 creator A5030829436 @default.
- W1966227539 creator A5043094856 @default.
- W1966227539 date "2008-08-20" @default.
- W1966227539 modified "2023-10-06" @default.
- W1966227539 title "Mass spectrometry for structural characterization of therapeutic antibodies" @default.
- W1966227539 cites W1513689832 @default.
- W1966227539 cites W1518819083 @default.
- W1966227539 cites W1550340517 @default.
- W1966227539 cites W1568538568 @default.
- W1966227539 cites W1605996579 @default.
- W1966227539 cites W1807371590 @default.
- W1966227539 cites W1963522035 @default.
- W1966227539 cites W1964723513 @default.
- W1966227539 cites W1964905214 @default.
- W1966227539 cites W1965346411 @default.
- W1966227539 cites W1966025897 @default.
- W1966227539 cites W1966510993 @default.
- W1966227539 cites W1966625877 @default.
- W1966227539 cites W1968037422 @default.
- W1966227539 cites W1968481765 @default.
- W1966227539 cites W1969249762 @default.
- W1966227539 cites W1969317566 @default.
- W1966227539 cites W1971239924 @default.
- W1966227539 cites W1971622553 @default.
- W1966227539 cites W1971922215 @default.
- W1966227539 cites W1971983473 @default.
- W1966227539 cites W1974472659 @default.
- W1966227539 cites W1974830441 @default.
- W1966227539 cites W1975086323 @default.
- W1966227539 cites W1975178001 @default.
- W1966227539 cites W1975715980 @default.
- W1966227539 cites W1975784741 @default.
- W1966227539 cites W1976165460 @default.
- W1966227539 cites W1976287795 @default.
- W1966227539 cites W1976790533 @default.
- W1966227539 cites W1977052017 @default.
- W1966227539 cites W1977494797 @default.
- W1966227539 cites W1977972652 @default.
- W1966227539 cites W1978041876 @default.
- W1966227539 cites W1978675849 @default.
- W1966227539 cites W1979626824 @default.
- W1966227539 cites W1979786011 @default.
- W1966227539 cites W1980017824 @default.
- W1966227539 cites W1980458819 @default.
- W1966227539 cites W1980650956 @default.
- W1966227539 cites W1980975384 @default.
- W1966227539 cites W1981417774 @default.
- W1966227539 cites W1981580797 @default.
- W1966227539 cites W1981788247 @default.
- W1966227539 cites W1982156268 @default.
- W1966227539 cites W1982468602 @default.
- W1966227539 cites W1982731674 @default.
- W1966227539 cites W1982911860 @default.
- W1966227539 cites W1983354426 @default.
- W1966227539 cites W1983519034 @default.
- W1966227539 cites W1983638944 @default.
- W1966227539 cites W1983984493 @default.
- W1966227539 cites W1985524611 @default.
- W1966227539 cites W1987565277 @default.
- W1966227539 cites W1988396270 @default.
- W1966227539 cites W1988585833 @default.
- W1966227539 cites W1988962987 @default.
- W1966227539 cites W1989904481 @default.
- W1966227539 cites W1991575564 @default.
- W1966227539 cites W1991903019 @default.
- W1966227539 cites W1993063472 @default.
- W1966227539 cites W1994391661 @default.
- W1966227539 cites W1994784215 @default.
- W1966227539 cites W1994809597 @default.
- W1966227539 cites W1996826403 @default.
- W1966227539 cites W1997292282 @default.
- W1966227539 cites W1997445789 @default.
- W1966227539 cites W1997454591 @default.
- W1966227539 cites W1998744147 @default.
- W1966227539 cites W1998922103 @default.
- W1966227539 cites W1999139162 @default.
- W1966227539 cites W2000586536 @default.
- W1966227539 cites W2000813502 @default.
- W1966227539 cites W2001292969 @default.
- W1966227539 cites W2004290717 @default.
- W1966227539 cites W2007527241 @default.
- W1966227539 cites W2008405327 @default.
- W1966227539 cites W2011024907 @default.
- W1966227539 cites W2012509110 @default.
- W1966227539 cites W2013228860 @default.
- W1966227539 cites W2013234985 @default.
- W1966227539 cites W2014405882 @default.
- W1966227539 cites W2014609429 @default.
- W1966227539 cites W2015840688 @default.
- W1966227539 cites W2016527134 @default.
- W1966227539 cites W2016928464 @default.
- W1966227539 cites W2017515622 @default.
- W1966227539 cites W2017792299 @default.
- W1966227539 cites W2018172073 @default.
- W1966227539 cites W2018252822 @default.