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• W1966235711 abstract "To investigate the feasibility of T(1) -weighted dynamic contrast-enhanced (DCE) MRI for the measurement of brain perfusion.Dynamic imaging was performed on a 3.0 Tesla (T) MR scanner by using a rapid spoiled-GRE protocol. T(1) measurement with driven equilibrium single pulse observation of T(1) (DESPOT1) was used to convert the MR signal to tracer concentration. Cerebral perfusion maps were obtained by using an improved gamma-variate model in 10 subjects and compared with those with arterial spin label (ASL) approach.The cerebral blood volume (CBV) values were calculated as 4.74 ± 1.09 and 2.29 ± 0.58 mL/100 g in gray matter (GM) and whiter matter (WM), respectively. Mean transit time (MTT) values were 6.15 ± 0.59 s in GM and 6.96 ± 0.79 s in WM. The DCE values for GM/WM cerebral blood flow (CBF) were measured as 53.41 ± 9.23 / 25.78 ± 8.91 mL/100 g/min, versus ASL values of 49.05 ± 10.81 / 23.00 ± 5.89 mL/100 g/min for GW/WM. Bland-Altman plot revealed a small difference of CBF between two approaches (mean bias = 3.83 mL/100 g/min, SD = 11.29). There were 6 pairs of samples (5%, 6/120) beyond the 95% limits of agreement. The correlation plots showed that the slop of Y (CBF_(_DCE)) versus X intercept (CBF_(_ASL)) is 0.95 with the intercept of 4.53 mL/100 g/min (r = 0.74; P < 0.05).It is feasible to evaluate the cerebral perfusion by using T(1)-weighted DCE-MRI with the improved kinetic model." @default.
• W1966235711 created "2016-06-24" @default.
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• W1966235711 date "2012-02-07" @default.
• W1966235711 modified "2023-09-25" @default.
• W1966235711 title "Feasibility study of exploring a T1-weighted dynamic contrast-enhanced MR approach for brain perfusion imaging" @default.
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• W1966235711 doi "https://doi.org/10.1002/jmri.23570" @default.
• W1966235711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22314848" @default.
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