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- W1966237369 abstract "This chapter discusses the important role of intrathecal drug delivery for the treatment of chronic cancer and non-cancer pain. Specific diagnostic considerations and the role of an intrathecal trial for appropriate patient selection are discussed in depth. There are presently only two intrathecal agents approved for use by the FDA in chronic pain therapy, including morphine (an opioid), and ziconitide (a non-opioid calcium channel antagonist). Current recommendations, supporting evidence, and safety profiles of both FDA approved and off-label intrathecal medications for pain control are reviewed. The roles of combination intrathecal therapy and dual modality therapy in conjunction with spinal cord stimulation are also briefly discussed. Finally, the process of surgical implantation, commonly used drug delivery systems, and associated post-implant and pharmacologic complications are described in detail." @default.
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- W1966237369 date "1997-09-01" @default.
- W1966237369 modified "2023-09-23" @default.
- W1966237369 title "Intrathecal granuloma after implantation of a morphine pump: Case report and review of the literature" @default.
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- W1966237369 doi "https://doi.org/10.1016/s0090-3019(96)00466-1" @default.
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