Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966244079> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1966244079 endingPage "320" @default.
- W1966244079 startingPage "315" @default.
- W1966244079 abstract "The effects of p-chlorophenylalanine (PCPA, 100-150 mg/kg x 1. i.p.), doses which decrease brain 5-hydroxytryptamine (5-HT) by 30-50%, were investigated in both intact rats and 14 days after giving p-chloroamphetamine (PCA, 10 mg/kg/day x 2, i.p.). The PCPA dose-dependently decreased brain regional 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) 24 hr later. As per cent decreases of 5-HIAA were greater than those of 5-HT in cortex, striatum and hippocampus 5-HIAA/5-HT ratios fell, suggesting that partial inhibition of 5-HT synthesis by PCPA increases 5-HT conservation in these terminal regions. In the hypothalamus and brain stem, decreases of the ratio were small or absent. The PCA given without subsequent PCPA treatment decreased 5-HT and 5-HIAA so that 5-HT fell by about 70% in the cortex, striatum and hippocampus, 55% in the brain stem but only by 27% in the hypothalamus. The PCPA given after PCA decreased 5-HT and 5-HIAA further but not the 5-HIAA/5-HT ratios and increased the ratio in the brain stem. The 5-HIAA/5-HT findings imply that the increase of 5-HT conservation after PCPA treatment does not occur after partial depletion of 5-HT by PCA. The increase of the 5-HIAA/5-HT ratio in the brain stem is explicable by the resistance to both PCA and PCPA of 5-HT in cell bodies where the ratio is high. Results are discussed in relation to the question of whether the PCA treatment used destroys axon terminals projecting from the dorsal but not from the median raphe." @default.
- W1966244079 created "2016-06-24" @default.
- W1966244079 creator A5073501588 @default.
- W1966244079 creator A5091653196 @default.
- W1966244079 date "1996-03-01" @default.
- W1966244079 modified "2023-10-07" @default.
- W1966244079 title "Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats" @default.
- W1966244079 cites W1693348571 @default.
- W1966244079 cites W1964197979 @default.
- W1966244079 cites W1966248544 @default.
- W1966244079 cites W1968343380 @default.
- W1966244079 cites W1972638622 @default.
- W1966244079 cites W1973163590 @default.
- W1966244079 cites W1975695457 @default.
- W1966244079 cites W1978769057 @default.
- W1966244079 cites W1990021692 @default.
- W1966244079 cites W1999261054 @default.
- W1966244079 cites W2002878426 @default.
- W1966244079 cites W2004332815 @default.
- W1966244079 cites W2024766532 @default.
- W1966244079 cites W2034146177 @default.
- W1966244079 cites W2050152098 @default.
- W1966244079 cites W2050448984 @default.
- W1966244079 cites W2054876475 @default.
- W1966244079 cites W2072209030 @default.
- W1966244079 cites W2073866710 @default.
- W1966244079 cites W2078909485 @default.
- W1966244079 cites W2119505982 @default.
- W1966244079 doi "https://doi.org/10.1016/0028-3908(96)00175-x" @default.
- W1966244079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8783206" @default.
- W1966244079 hasPublicationYear "1996" @default.
- W1966244079 type Work @default.
- W1966244079 sameAs 1966244079 @default.
- W1966244079 citedByCount "27" @default.
- W1966244079 countsByYear W19662440792012 @default.
- W1966244079 countsByYear W19662440792013 @default.
- W1966244079 countsByYear W19662440792015 @default.
- W1966244079 countsByYear W19662440792017 @default.
- W1966244079 crossrefType "journal-article" @default.
- W1966244079 hasAuthorship W1966244079A5073501588 @default.
- W1966244079 hasAuthorship W1966244079A5091653196 @default.
- W1966244079 hasConcept C126322002 @default.
- W1966244079 hasConcept C134018914 @default.
- W1966244079 hasConcept C169760540 @default.
- W1966244079 hasConcept C170493617 @default.
- W1966244079 hasConcept C185592680 @default.
- W1966244079 hasConcept C2775864247 @default.
- W1966244079 hasConcept C2777003273 @default.
- W1966244079 hasConcept C2777348757 @default.
- W1966244079 hasConcept C2779164789 @default.
- W1966244079 hasConcept C2780062018 @default.
- W1966244079 hasConcept C2781041448 @default.
- W1966244079 hasConcept C2781161787 @default.
- W1966244079 hasConcept C2910298800 @default.
- W1966244079 hasConcept C37000724 @default.
- W1966244079 hasConcept C513476851 @default.
- W1966244079 hasConcept C53910766 @default.
- W1966244079 hasConcept C71924100 @default.
- W1966244079 hasConcept C86803240 @default.
- W1966244079 hasConceptScore W1966244079C126322002 @default.
- W1966244079 hasConceptScore W1966244079C134018914 @default.
- W1966244079 hasConceptScore W1966244079C169760540 @default.
- W1966244079 hasConceptScore W1966244079C170493617 @default.
- W1966244079 hasConceptScore W1966244079C185592680 @default.
- W1966244079 hasConceptScore W1966244079C2775864247 @default.
- W1966244079 hasConceptScore W1966244079C2777003273 @default.
- W1966244079 hasConceptScore W1966244079C2777348757 @default.
- W1966244079 hasConceptScore W1966244079C2779164789 @default.
- W1966244079 hasConceptScore W1966244079C2780062018 @default.
- W1966244079 hasConceptScore W1966244079C2781041448 @default.
- W1966244079 hasConceptScore W1966244079C2781161787 @default.
- W1966244079 hasConceptScore W1966244079C2910298800 @default.
- W1966244079 hasConceptScore W1966244079C37000724 @default.
- W1966244079 hasConceptScore W1966244079C513476851 @default.
- W1966244079 hasConceptScore W1966244079C53910766 @default.
- W1966244079 hasConceptScore W1966244079C71924100 @default.
- W1966244079 hasConceptScore W1966244079C86803240 @default.
- W1966244079 hasIssue "3" @default.
- W1966244079 hasLocation W19662440791 @default.
- W1966244079 hasLocation W19662440792 @default.
- W1966244079 hasOpenAccess W1966244079 @default.
- W1966244079 hasPrimaryLocation W19662440791 @default.
- W1966244079 hasRelatedWork W100334271 @default.
- W1966244079 hasRelatedWork W1968957681 @default.
- W1966244079 hasRelatedWork W1986899295 @default.
- W1966244079 hasRelatedWork W2038624063 @default.
- W1966244079 hasRelatedWork W2044162202 @default.
- W1966244079 hasRelatedWork W2075185510 @default.
- W1966244079 hasRelatedWork W2094542200 @default.
- W1966244079 hasRelatedWork W2116634575 @default.
- W1966244079 hasRelatedWork W3098068347 @default.
- W1966244079 hasRelatedWork W4232217230 @default.
- W1966244079 hasVolume "35" @default.
- W1966244079 isParatext "false" @default.
- W1966244079 isRetracted "false" @default.
- W1966244079 magId "1966244079" @default.
- W1966244079 workType "article" @default.