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- W1966245180 abstract "From January to March, 1974, twenty-four cases of Reye's syndrome encephalopathy and fatty liver) were diagnosed in Cincinnati, Ohio. The epidemic coincided with an epidemic of influenza B, intermediate type. In eighteen of twenty-three cases (78%) in which viral studies were done, an acute viral infection was found in either the patient or a close contact with similar prodromal symptoms. Influenza-B infection was confirmed in twelve patients and twelve contacts, although influenza A, parainfluenza 1, adenovirus, and varicella-zoster virus infections also occurred. In four cases there was evidence of two different viruses infecting the patients or their contacts. Cellular immunity was studied in six cases and responses to phytohæmagglutinin and specific viral antigen were normal. This is the first epidemic of Reye's syndrome in which the association with viral infection has been confirmed in most patients by virological techniques. Impaired cellular immunity could not be implicated as the cause of the unusual reponse to infection." @default.
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- W1966245180 date "1974-07-01" @default.
- W1966245180 modified "2023-09-26" @default.
- W1966245180 title "ASSOCIATION OF REYE'S SYNDROME WITH VIRAL INFECTION" @default.
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- W1966245180 doi "https://doi.org/10.1016/s0140-6736(74)91481-0" @default.
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