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• W1966248625 startingPage "105" @default.
• W1966248625 abstract "Plasminogen activity and DNA synthesis by epidermal cells have been reported to be doubled in psoriatic skin grafts compared with grafts of normal skin 6 weeks after transplantation to nude mice. In our study human lymphocytes disappeared from such grafts within 48 h whilst some DR-positive human dendritic cells were retained in the grafts for up to 4 weeks. However, the grafts were infiltrated by Thy 1.2+ mouse lymphocytes within 6 days and this infiltration persisted at a moderate level throughout the observation period. It consisted of perivascular aggregates, scattered dermal and papillary T cells, and some mouse T cells were also found in the epidermal compartment. Grafts of psoriatic and non-psoriatic control skin were infiltrated to a similar extent, suggesting a low-grade rejection response against the human xenografts. These findings raise the possibility that psoriatic keratinocytes are responding abnormally to inflammatory cytokines released by mouse lymphocytes reacting against the skin grafts." @default.
• W1966248625 created "2016-06-24" @default.
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• W1966248625 date "1992-02-01" @default.
• W1966248625 modified "2023-09-29" @default.
• W1966248625 title "Is epidermal cell proliferation in psoriatic skin grafts on nude mice driven by T-cell derived cytokines?" @default.
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• W1966248625 doi "https://doi.org/10.1111/j.1365-2133.1992.tb07805.x" @default.
• W1966248625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1536776" @default.
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