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- W1966249609 abstract "A 32-year-old female had been diagnosed as having relapsed breast cancer and liver metastasis. She underwent high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) with 5.8 x 10(6)/kg CD34+ cells. She was supported by total parenteral nutrition (TPN) without vitamins throughout these therapies. Hematopoietic recovery was not observed by day 28 after PBSCT, necessitating a second PBSCT on day 29 using the back-up material of 4.4 x 10(6)/kg CD34+ cells. On the next day, she suddenly developed severe metabolic acidosis, heart failure and deep coma. After immediate infusion of thiamine, heart failure and coma rapidly improved. The neutrophil count reached 0.5 x 10(9)/l on day 9 and the platelet count 50 x 10(9)/l on day 15 after the second PBSCT. This is a rare graft failure due to acute metabolic acidosis or thiamine deficiency associated with TPN." @default.
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- W1966249609 date "1999-01-01" @default.
- W1966249609 modified "2023-10-16" @default.
- W1966249609 title "Graft Failure of Autologous Peripheral Blood Stem Cell Transplantation due to Acute Metabolic Acidosis Associated with Total Parenteral Nutrition in a Patient with Relapsed Breast Cancer" @default.
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- W1966249609 doi "https://doi.org/10.1159/000040992" @default.
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