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- W1966250010 endingPage "1335" @default.
- W1966250010 startingPage "1326" @default.
- W1966250010 abstract "Chronic infection with the hepatitis B and C virus represents a major health problem worldwide, as it is estimated that roughly 400 and 200 million people respectively, are infected by each virus. By definition, any antiviral therapy that claims to be effective should have as its ultimate efficacy end point an improvement in patients' survival, or at least a reduction in the development rates of liver-related complications. However, this is extremely complicated to prove as the natural course of both viral diseases is extremely slow, requiring decades to evolve in cirrhosis and even more years to lead to liver complications. For this reason, clinicians and health authorities have relied on so called surrogate end points to assess the efficacy of any therapeutic intervention for viral hepatitis. Obviously, this allows for standardization in study designs that ultimately translates into an accelerated time frame for therapeutic drugs as well as healthcare innovations to enter the viral hepatitis clinical practice. However, it also calls for demonstration that surrogate end points in the treatment of patients with chronic hepatitis B or C are good and reliable markers of long-term efficacy." @default.
- W1966250010 created "2016-06-24" @default.
- W1966250010 creator A5014753999 @default.
- W1966250010 creator A5040002369 @default.
- W1966250010 creator A5074836130 @default.
- W1966250010 date "2012-12-01" @default.
- W1966250010 modified "2023-09-25" @default.
- W1966250010 title "Assessing long-term treatment efficacy in chronic hepatitis B and C: Between evidence and common sense" @default.
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- W1966250010 doi "https://doi.org/10.1016/j.jhep.2012.06.025" @default.
- W1966250010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22750749" @default.
- W1966250010 hasPublicationYear "2012" @default.