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• W1966252938 endingPage "240" @default.
• W1966252938 startingPage "240" @default.
• W1966252938 abstract "Rates of tuberculosis (TB) are increasing in most west European nations. Patients with TB can be admitted to an ICU for a variety of reasons, including respiratory failure, multiorgan failure and decreased consciousness associated with central nervous system disease. TB is a treatable disease but the mortality for patients admitted with TB to an ICU remains high. Management challenges exist in establishing a prompt diagnosis and administering effective treatment on the ICU with potentially poor gastric absorption and high rates of organ dysfunction and drug toxicity. In this review reasons for ICU admission, methods of achieving a confident diagnosis through direct and inferred methods, anti-tuberculosis treatment (including steroid and other adjuvant therapies) and specific management problems with particular relevance to the intensivist are discussed. The role of therapeutic drug monitoring, judicious use of alternative regimes in the context of toxicity or organ dysfunction and when to suspect paradoxical tuberculosis reactions are also covered. Diagnostic and therapeutic algorithms are proposed to guide ICU doctors in the management of this sometimes complicated disease." @default.
• W1966252938 created "2016-06-24" @default.
• W1966252938 creator A5027645783 @default.
• W1966252938 creator A5070422637 @default.
• W1966252938 date "2013-01-01" @default.
• W1966252938 modified "2023-09-29" @default.
• W1966252938 title "Clinical review: Tuberculosis on the intensive care unit" @default.
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• W1966252938 doi "https://doi.org/10.1186/cc12760" @default.
• W1966252938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4056111" @default.
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• W1966252938 hasPublicationYear "2013" @default.
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