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- W1966258839 abstract "The phylum Porifera (sponges) was the first to diverge from the common ancestor of the Metazoa. In this study, six cDNAs coding for protein-serine/threonine kinases (PS/TKs) are presented; they have been isolated from libraries obtained from the demosponges Geodia cydonium and Suberites domuncula and from the calcareous sponge Sycon raphanus. Sequence alignments of the catalytic domains revealed that two major families of PS/TK, the conventional (Ca(2+)-dependent) protein kinase C (PKC), the cPKC subfamily, as well as the novel (Ca(2+)-independent) PKC (nPKC), form two separate clusters. In each cluster, the sequence from S. raphanus diverges first. To approach the question about the origin of protein-tyrosine kinases (PTK), which are found only in Metazoa, we analyzed two additional PS/TKs which have been cloned from S. domuncula: the stress-responsive protein kinase (KRSvSD) and the protein-kinase-C-related kinase (PRKvSD). The construction of the phylogenetic tree, comprising the eight PS/TKs and the PTK cloned previously from G. cydonium, revealed that the PTK derived from the branch including the KRSvSD kinase. These data facilitate the first molecular approach to elucidate the origin of metazoan PTK within the PS/TK superfamily." @default.
- W1966258839 created "2016-06-24" @default.
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- W1966258839 date "1997-12-01" @default.
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- W1966258839 title "Early evolution of metazoan serine/threonine and tyrosine kinases: identification of selected kinases in marine sponges" @default.
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- W1966258839 doi "https://doi.org/10.1093/oxfordjournals.molbev.a025742" @default.
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