FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966261503> ?p ?o ?g. }

• W1966261503 endingPage "238" @default.
• W1966261503 startingPage "229" @default.
• W1966261503 abstract "Previous electrophysiological experiments have emphasized the importance of the firing pattern for the functioning of midbrain dopamine (DA) neurons. In this regard, excitatory amino acid receptors appear to constitute an important modulatory control mechanism. In the present study, extracellular recording techniques were used to investigate the significance of GABAB-receptor activation for the firing properties of DA neurons in the substantia nigra (SN) in the rat. Intravenous administration of the GABAB-receptor agonist baclofen (1–16 mg/kg) was associated with a dose-dependent regularisation of the firing pattern, concomitant with a reduction in burst firing. At higher doses (16–32 mg/kg), the firing rate of the DA neurons was dose-dependently decreased. Also, microiontophoretic application of baclofen regularized the firing pattern of nigral DA neurons, including a reduction of burst firing. Both the regularisation of the firing pattern and inhibition of firing rate produced by systemic baclofen administration was antagonized by the GABAB-receptor antagonist CGP 35348 (200 mg/kg, l.v.). The GABAA-receptor agonist muscimol produced effects on the firing properties of DA neurons that were opposite to those observed following baclofen, i.e., an increase in firing rate accompanied by a Cecreased regularity. The NMDA receptor antagonist MK 801 (0.4–3.2 mg/kg, i.v.) produced a moderate, dose-dependent increase in the firing rate of the nigral DA neurons as well as a slightly regularized firing pattern. Pretreatment with MK 801 (3.2 mg/kg, i.v., 3–10 min) did neither promote nor prevent the regularisation of the firing pattern or inhibition of firing rate on the nigral DA neurons produced by baclofen. The present results clearly show that GABAB-receptors can alter the firing pattern of nigral DA neurons, hereby counterbalancing the previously described ability of glutamate to induce burst Firing activity on these neurons. © 1993 Wiley-Liss, Inc." @default.
• W1966261503 created "2016-06-24" @default.
• W1966261503 creator A5050993740 @default.
• W1966261503 creator A5055128103 @default.
• W1966261503 creator A5082534846 @default.
• W1966261503 date "1993-11-01" @default.
• W1966261503 modified "2023-09-26" @default.
• W1966261503 title "GABAB-Receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra" @default.
• W1966261503 cites W1633847368 @default.
• W1966261503 cites W1840984304 @default.
• W1966261503 cites W1949404224 @default.
• W1966261503 cites W1969187530 @default.
• W1966261503 cites W1971092962 @default.
• W1966261503 cites W1978355864 @default.
• W1966261503 cites W1981910248 @default.
• W1966261503 cites W1984838114 @default.
• W1966261503 cites W1989176150 @default.
• W1966261503 cites W1992587213 @default.
• W1966261503 cites W1992603366 @default.
• W1966261503 cites W1992894736 @default.
• W1966261503 cites W1995056605 @default.
• W1966261503 cites W1996725336 @default.
• W1966261503 cites W2000359896 @default.
• W1966261503 cites W2003695782 @default.
• W1966261503 cites W2004195455 @default.
• W1966261503 cites W2007719501 @default.
• W1966261503 cites W2008035173 @default.
• W1966261503 cites W2009195573 @default.
• W1966261503 cites W2009809272 @default.
• W1966261503 cites W2014796143 @default.
• W1966261503 cites W2016723993 @default.
• W1966261503 cites W2022600505 @default.
• W1966261503 cites W2028864767 @default.
• W1966261503 cites W2029866235 @default.
• W1966261503 cites W2034946495 @default.
• W1966261503 cites W2036649970 @default.
• W1966261503 cites W2039087606 @default.
• W1966261503 cites W2044592541 @default.
• W1966261503 cites W2047172433 @default.
• W1966261503 cites W2047941069 @default.
• W1966261503 cites W2052218769 @default.
• W1966261503 cites W2052676993 @default.
• W1966261503 cites W2052957595 @default.
• W1966261503 cites W2056279470 @default.
• W1966261503 cites W2057232383 @default.
• W1966261503 cites W2059919836 @default.
• W1966261503 cites W2063314485 @default.
• W1966261503 cites W2065521003 @default.
• W1966261503 cites W2066991732 @default.
• W1966261503 cites W2070456678 @default.
• W1966261503 cites W2073734156 @default.
• W1966261503 cites W2078476436 @default.
• W1966261503 cites W2090389195 @default.
• W1966261503 cites W2093024075 @default.
• W1966261503 cites W2098146506 @default.
• W1966261503 cites W2126680030 @default.
• W1966261503 cites W2129717318 @default.
• W1966261503 cites W2157658985 @default.
• W1966261503 cites W2173076039 @default.
• W1966261503 cites W2402721223 @default.
• W1966261503 cites W4236212944 @default.
• W1966261503 doi "https://doi.org/10.1002/syn.890150308" @default.
• W1966261503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8278899" @default.
• W1966261503 hasPublicationYear "1993" @default.
• W1966261503 type Work @default.
• W1966261503 sameAs 1966261503 @default.
• W1966261503 citedByCount "99" @default.
• W1966261503 countsByYear W19662615032012 @default.
• W1966261503 countsByYear W19662615032014 @default.
• W1966261503 countsByYear W19662615032015 @default.
• W1966261503 countsByYear W19662615032016 @default.
• W1966261503 countsByYear W19662615032017 @default.
• W1966261503 countsByYear W19662615032018 @default.
• W1966261503 countsByYear W19662615032020 @default.
• W1966261503 countsByYear W19662615032021 @default.
• W1966261503 countsByYear W19662615032022 @default.
• W1966261503 crossrefType "journal-article" @default.
• W1966261503 hasAuthorship W1966261503A5050993740 @default.
• W1966261503 hasAuthorship W1966261503A5055128103 @default.
• W1966261503 hasAuthorship W1966261503A5082534846 @default.
• W1966261503 hasConcept C101027131 @default.
• W1966261503 hasConcept C137183658 @default.
• W1966261503 hasConcept C169760540 @default.
• W1966261503 hasConcept C170493617 @default.
• W1966261503 hasConcept C185592680 @default.
• W1966261503 hasConcept C195221683 @default.
• W1966261503 hasConcept C2776885963 @default.
• W1966261503 hasConcept C2778122271 @default.
• W1966261503 hasConcept C2778296116 @default.
• W1966261503 hasConcept C2778938600 @default.
• W1966261503 hasConcept C2779188335 @default.
• W1966261503 hasConcept C2780938664 @default.
• W1966261503 hasConcept C2781201050 @default.
• W1966261503 hasConcept C513476851 @default.
• W1966261503 hasConcept C55493867 @default.
• W1966261503 hasConcept C67018056 @default.
• W1966261503 hasConcept C86803240 @default.
• W1966261503 hasConcept C98274493 @default.

• next