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- W1966262422 abstract "Parkinson's disease (PD) is the second most common neurodegenerative disorder. Several single gene mutations have been linked to this disease. Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) indicate LRRK2 as promising therapeutic target for the treatment of PD. LRRK2 mutations were observed in sporadic as well as familial PD patients and have been investigated intensively. LRRK2 is a large and complex protein, with multiple enzymatic and protein-interaction domains, each of which is effected by mutations. The most common mutation in PD patients is G2019S. Several LRRK2 inhibitors have been reported already, although the crystal structure of LRRK2 has not yet been determined. This review provides a summary of known LRRK2 inhibitors and will discuss recent in vitro and in vivo results of these inhibitors." @default.
- W1966262422 created "2016-06-24" @default.
- W1966262422 creator A5026635178 @default.
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- W1966262422 creator A5048371616 @default.
- W1966262422 creator A5082434236 @default.
- W1966262422 creator A5085908396 @default.
- W1966262422 date "2012-02-06" @default.
- W1966262422 modified "2023-10-11" @default.
- W1966262422 title "Small Molecule Kinase Inhibitors for LRRK2 and Their Application to Parkinson's Disease Models" @default.
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- W1966262422 doi "https://doi.org/10.1021/cn200117j" @default.
- W1966262422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3369800" @default.
- W1966262422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22860184" @default.
- W1966262422 hasPublicationYear "2012" @default.
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