Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966263246> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1966263246 endingPage "668" @default.
- W1966263246 startingPage "668" @default.
- W1966263246 abstract "Although double-strand breaks have long been recognized as an important type of DNA lesion, it is well established that this broad class of damage does not correlate well with indicators of the effectiveness of radiation at the cellular level. Assays of double-strand breaks do not distinguish the degree of complexity or clustering of singly damaged sites produced in a single energy deposition event, which is currently hypothesized to be key to understanding cellular end points. As a step toward this understanding, double-strand breaks that are formed proportionally to dose in plasmid DNA are analyzed from the mechanistic aspect to evaluate the yield that arises from multiply damaged sites as hypothesized by Ward (Prog. Nucleic Acid Res. Mol. Biol. 35, 95-125, 1988) and Goodhead (Int. J. Radiat, Biol. 65, 7-17, 1994) as opposed to the yield that arises from single hydroxyl radicals as hypothesized by Siddiqi and Bothe (Radiat. Res. 112, 449-463, 1987). For low-LET radiation such as gamma rays, the importance of multiply damaged sites is shown to increase with the solution's hydroxyl radical scavenging capacity. For moderately high-LET radiation such as 100 keV/micron helium ions, a much different behavior is observed. In this case, a large fraction of double-strand breaks are formed as a result of multiply damaged sites over a broad range of scavenging conditions. Results also indicate that the RBE for common cellular end points correlates more closely with the RBE for multiply damaged sites than with the RBE for total double-strand breaks over a range of LET up to at least 100 keV/micron." @default.
- W1966263246 created "2016-06-24" @default.
- W1966263246 creator A5014970645 @default.
- W1966263246 creator A5015685880 @default.
- W1966263246 date "1996-12-01" @default.
- W1966263246 modified "2023-09-25" @default.
- W1966263246 title "Modeling the Yield of Double-Strand Breaks Due to Formation of Multiply Damaged Sites in Irradiated Plasmid DNA" @default.
- W1966263246 cites W1483306411 @default.
- W1966263246 cites W1917341586 @default.
- W1966263246 cites W1974266806 @default.
- W1966263246 cites W1983001896 @default.
- W1966263246 cites W1999666772 @default.
- W1966263246 cites W2003534574 @default.
- W1966263246 cites W2003675334 @default.
- W1966263246 cites W2004498595 @default.
- W1966263246 cites W2015460353 @default.
- W1966263246 cites W2019963243 @default.
- W1966263246 cites W2026515265 @default.
- W1966263246 cites W2039558739 @default.
- W1966263246 cites W2041066010 @default.
- W1966263246 cites W2068449224 @default.
- W1966263246 cites W2074470990 @default.
- W1966263246 cites W2075328622 @default.
- W1966263246 cites W2125811746 @default.
- W1966263246 cites W2129176270 @default.
- W1966263246 cites W2312209333 @default.
- W1966263246 cites W2473812207 @default.
- W1966263246 doi "https://doi.org/10.2307/3579383" @default.
- W1966263246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8955717" @default.
- W1966263246 hasPublicationYear "1996" @default.
- W1966263246 type Work @default.
- W1966263246 sameAs 1966263246 @default.
- W1966263246 citedByCount "11" @default.
- W1966263246 countsByYear W19662632462014 @default.
- W1966263246 countsByYear W19662632462015 @default.
- W1966263246 crossrefType "journal-article" @default.
- W1966263246 hasAuthorship W1966263246A5014970645 @default.
- W1966263246 hasAuthorship W1966263246A5015685880 @default.
- W1966263246 hasConcept C111337013 @default.
- W1966263246 hasConcept C121332964 @default.
- W1966263246 hasConcept C12554922 @default.
- W1966263246 hasConcept C134121241 @default.
- W1966263246 hasConcept C139066938 @default.
- W1966263246 hasConcept C143425029 @default.
- W1966263246 hasConcept C145148216 @default.
- W1966263246 hasConcept C153428861 @default.
- W1966263246 hasConcept C177322064 @default.
- W1966263246 hasConcept C178790620 @default.
- W1966263246 hasConcept C185544564 @default.
- W1966263246 hasConcept C185592680 @default.
- W1966263246 hasConcept C24107716 @default.
- W1966263246 hasConcept C2992406208 @default.
- W1966263246 hasConcept C552990157 @default.
- W1966263246 hasConcept C55493867 @default.
- W1966263246 hasConcept C86611320 @default.
- W1966263246 hasConcept C86803240 @default.
- W1966263246 hasConcept C97355855 @default.
- W1966263246 hasConceptScore W1966263246C111337013 @default.
- W1966263246 hasConceptScore W1966263246C121332964 @default.
- W1966263246 hasConceptScore W1966263246C12554922 @default.
- W1966263246 hasConceptScore W1966263246C134121241 @default.
- W1966263246 hasConceptScore W1966263246C139066938 @default.
- W1966263246 hasConceptScore W1966263246C143425029 @default.
- W1966263246 hasConceptScore W1966263246C145148216 @default.
- W1966263246 hasConceptScore W1966263246C153428861 @default.
- W1966263246 hasConceptScore W1966263246C177322064 @default.
- W1966263246 hasConceptScore W1966263246C178790620 @default.
- W1966263246 hasConceptScore W1966263246C185544564 @default.
- W1966263246 hasConceptScore W1966263246C185592680 @default.
- W1966263246 hasConceptScore W1966263246C24107716 @default.
- W1966263246 hasConceptScore W1966263246C2992406208 @default.
- W1966263246 hasConceptScore W1966263246C552990157 @default.
- W1966263246 hasConceptScore W1966263246C55493867 @default.
- W1966263246 hasConceptScore W1966263246C86611320 @default.
- W1966263246 hasConceptScore W1966263246C86803240 @default.
- W1966263246 hasConceptScore W1966263246C97355855 @default.
- W1966263246 hasIssue "6" @default.
- W1966263246 hasLocation W19662632461 @default.
- W1966263246 hasLocation W19662632462 @default.
- W1966263246 hasOpenAccess W1966263246 @default.
- W1966263246 hasPrimaryLocation W19662632461 @default.
- W1966263246 hasRelatedWork W1976195362 @default.
- W1966263246 hasRelatedWork W1997078215 @default.
- W1966263246 hasRelatedWork W2009540037 @default.
- W1966263246 hasRelatedWork W2042743402 @default.
- W1966263246 hasRelatedWork W2059177774 @default.
- W1966263246 hasRelatedWork W2368141771 @default.
- W1966263246 hasRelatedWork W2472220583 @default.
- W1966263246 hasRelatedWork W2741063239 @default.
- W1966263246 hasRelatedWork W2903111768 @default.
- W1966263246 hasRelatedWork W3025451886 @default.
- W1966263246 hasVolume "146" @default.
- W1966263246 isParatext "false" @default.
- W1966263246 isRetracted "false" @default.
- W1966263246 magId "1966263246" @default.
- W1966263246 workType "article" @default.